Genetic testing for BRCA1/2 mutations associated with hereditary breast and ovarian cancer reveals significant risk info...
...BRCA1-deficient HCC1937 cells are more sensitive to mitomycin C (MMC) compared to GM00637 and MCF-7 cells. The evidence ...
...BRCA1/2 mutation carriers have demonstrated the existence of serous tubal intraepithelial carcinomas (STIC). Further stu...
...BRCA1 protein, as well as PARP-1 polymerase, possess weak sequence specific DNA binding yet bind preferentially to cruci...
Poly (ADP-ribose) polymerase (PARP) inhibitors effectively kill tumours defective in the BRCA1 or BRCA2 genes through th...
...BRCA1). Extended genomic regions harboring manifold combinations of physically and/or functionally related genes and reg...
BRCA1 is a major gatekeeper of genomic stability. Acting in multiple central processes like double-strand break repair, ...
In this study, we compared the gene targeting efficiencies of two rAAV-BRCA1 KO targeting constructs in Yucatan and Gött...
...BRCA1 and p53, and a decrease in several angiogenic factors. The phosphorylated forms of MAPK p42/44 and AKT were lower ...
Inherited loss-of-function mutations in BRCA1 and BRCA2 and other tumor suppressor genes predispose to ovarian carcinoma...
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