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A common environmental carcinogen unduly affects carriers of cancer mutations: …

Friedenson(Bernard) Med Hypotheses 2012-02-01

...BRCA1 or BRCA2 mutations also increase risks for myeloid leukemias in 11 of 12 relevant studies. BRCA1/2 mutation carrie...

DNA damage response signaling in lung adenocarcinoma A549 cells following gamma…

Ghosh(Somnath),Narang(Himanshi),Sarma(Asitik… Mutat Res 2012-02-07

...BRCA1 foci were found in all carbon irradiated cells unlike γ-rays irradiated cells and prosurvival ERK pathway was acti...

Constitutive expression of γ-H2AX has prognostic relevance in triple negative b…

Nagelkerke(Anika),van Kuijk(Simon J A),Sweep… Radiother Oncol 2012-05-18

...BRCA1 (p=0.011) or p53 (p=0.053) mutations. Specifically in triple negative breast cancer patients a high number of γ-H2...

Recruitment of proteins to DNA double-strand breaks: MDC1 directly recruits RAP…

Strauss(Carmit),Goldberg(Michal) Cell Cycle 2012-03-19

...BRCA1 to DSBs. We provided evidences that the MDC1-RAP80 interaction depends on a ubiquitylation event on K-1977 of MDC1...

Ginkgo may prevent genetic-associated ovarian cancer risk: multiple biomarkers…

Jiang(Wei),Qiu(Weiliang),Wang(Yisheng),Cong(… Eur J Cancer Prev 2012-07-25

Women carrying BRCA1 mutations have a higher risk of developing ovarian cancers. Options to reduce this risk are largely...

BRCA1 R71K missense mutation contributes to cancer predisposition by increasing…

Zhang(Liying),Chen(Lishi),Bacares(Ruben),Rug… Breast Cancer Res Treat 2012-03-22

Mutation screening of the breast and ovarian cancer predisposition genes BRCA1 and BRCA2 is becoming an increasingly imp...

Characteristics of double heterozygosity for BRCA1 and BRCA2 germline mutations…

Noh(Jae Myoung),Choi(Doo Ho),Nam(Seok Jin),L… Breast Cancer Res Treat 2012-08-21

To investigate clinical, pathological, and familial characteristics of Korean patients with double heterozygosity for BR...

Mechanisms of increased risk of tumorigenesis in Atm and Brca1 double heterozyg…

Wang(Jufang),Su(Fengtao),Smilenov(Lubomir B)… Radiat Oncol 2012-04-09

...Brca1 heterozygosity.,Wild type cells, Atm or Brca1 single heterozygous cells, and Atm/Brca1 double heterozygous cells w...

Prospective study of breast cancer risk for mutation negative women from BRCA1 …

Harvey(S L),Milne(R L),McLachlan(S A),Friedl… Breast Cancer Res Treat 2012-03-22

...BRCA1 or BRCA2 mutation carrier from 224 mutation positive (128 BRCA1, 96 BRCA2) families, had no personal cancer histor...

Length of the active-site crossover loop defines the substrate specificity of u…

Zhou(Zi-Ren),Zhang(Yu-Hang),Liu(Shuai),Song(… Biochem J 2012-02-16

...BRCA1 (breast cancer early-onset 1)-associated protein 1], is able to cleave both small and large Ub derivatives, wherea...

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