...NF1) developed CNS tumors at an early age. In addition, one of them developed a T-cell lymphoma. Neither parent had NF1....
...NF1) in liver nuclear extracts to the 160 bp proximal promoter. Transfection of mutated and/or deletion constructs showe...
...NF1 in our patient could be attributed to mosaic hemizygosity for the NF1 gene in some of her somatic cells. A similar m...
...NF1. We show that NF1 loss activates a bypass pathway, which confers ERK dependency downstream of RAS activation. These ...
...NF1 and NF2 cases shows that the ratio of NF2:NF1 in childhood is approximately 1:100, and that the clinical features of...
Thoracic meningoceles (tMCs) are extremely rare, yet the majority occur in patients with Neurofibromatosis type 1 (NF1)....
...NF1-mutant breast cancer patient. This multi-organoid system enabled individualized assessment of drug absorption, distr...
...NF1). Both conditions typically involve café-au-lait macules, axillary freckling, and macrocephaly; however, patients wi...
Optic pathway gliomas are often asymptomatic tumors occurring in children with neurofibromatosis type 1 (NF1 + OPG) or s...
...NF1) loss of function (LoF) mutations are frequent in melanoma and drive hyperactivated RAS and tumor growth. NF1LoF mel...
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