BRCA1-associated protein 1 (BAP1) is frequently inactivated in pleural mesothelioma and functions as a tumor suppressor ...
...BRCA1/2 mutations, hypermethylation, and deregulation of retinoblastoma 1 and phosphatidylinositol 3-kinase (PI3K)/Akt/R...
...BRCA1/2 pathogenic variants, and NTRK fusions, each linked to approved therapeutic agents. The purpose of this review is...
...BRCA1, BRCA2, CHEK1, CHEK2, ATM, CDK12) in paired samples of normal and tumor tissue over a 24-h PMI using RT-qPCR. In n...
...BRCA1-associated protein 1) expression is a well-established adverse prognostic marker in uveal melanoma (UM). However, ...
...BRCA1 and 7.6 months (95% CI 3.4-12.0) for non-carriers. In subtype-stratified analyses, gBRCA1 showed similar mortality...
...BRCA1/2 PVs treated with PARPi. Outcomes included objective response rate (ORR), progression-free survival (PFS), and ov...
...BRCA1/ATR; immune infiltration revealed significant correlations with macrophages and CD8+ T cells, with hsa-miR-15a-5p ...
...BRCA1 promoter methylation occurred independently of BRCA1 mutational status. No significant associations were observed ...
...BRCA1/2 or PALB2 pathogenic variant, PARP inhibitors remain an option as maintenance treatment after achieving at least ...
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