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Malignant Peripheral Nerve Sheath Tumor (MPNST) Arising from Orbital Plexiform …

Friedrich(RE),Hagel(C) Cancer Diagn Progn 2025-00-00

Neurofibromatosis type 1 (NF1) is an autosomal dominant hereditary tumor predisposition syndrome. In approximately 30% o...

Combined Inactivation of MEK and mTOR Can Lead to Synergistic Cell Death in Gli…

Cornelissen(FMG),Broersma(Y),Narayan(RS),Dik… Mol Cancer Ther 2025-12-02

...NF1) alterations as well as transcriptomic defined GB subtypes]. Synergy levels were correlated to in-lab generated phos...

Phytotoxic Effects and Agricultural Potential of Nanofertilizers: A Study Using…

Zamora-Ledezma(E),Aragundi(GLL),Guamán Marqu… J Xenobiot 2025-08-01

...NF1 > NF3 > NF2 > NM2 > NM1 > NM3, with NF1 being most toxic (EC50 = 1.2%). Nanofertilizers caused 45-78% reductions in ...

Natural history of SPP1 signaling in NF1 tumors.

Njoya(K),Zayed(H),Sun(L),Alson(D),Aina(O),Kh… NPJ Precis Oncol 2025-10-06

...Nf1+/-;Trp53+/-;Spp1-/- configuration. Notably, our analysis of the pre-tumor stage in the DhhCre;Nf1-/- pNF mouse model...

Recurrent Diffuse Neurofibroma of the Mandibular Anterior Lingual Alveolar Proc…

Friedrich(RE),Kohlrusch(FK),Hagel(C) Cancer Diagn Progn 2025-00-00

...NF1. This 14-year-old patient with NF1 had developed a solid tumor arising from the mandibular anterior lingual alveolar...

Frequency and Characteristics of Gastrointestinal Diseases in Patients With Neu…

Honda(M),Iwamuro(M),Tanaka(T),Yamasaki(Y),Ka… JGH Open 2025-04-00

...NF1) and 15 with NF type 2 (NF2). None of the NF2 patients underwent endoscopy. Among the NF1 patients, 27 received endo...

Targeting Sporadic and Neurofibromatosis Type 1 (NF1) Related Refractory Malign…

Widemann(BC),Lu(Y),Reinke(D),Okuno(SH),Meyer… Sarcoma 2019-00-00

There are no known effective medical treatments for refractory MPNST. Inactivation of the NF1 tumor suppressor in MPNST ...

Five cases report and literature review of malignant peripheral nerve sheath tu…

Wu(X),Zhang(Y),Liu(X),Zhang(Q),Yang(Q),Zhang… Discov Oncol 2025-11-28

...NF1) in about 50% of cases. The overall incidence ranges from 3% to 10%, and it has been on the rise in recent years. Re...

Therapeutic drug monitoring of selumetinib in pediatrics: a combined LC-MS/MS a…

Cafaro(A),Santangelo(A),Barco(S),Corsini(C),… Front Pharmacol 2025-00-00

Neurofibromatosis type 1 (NF1) is a genetic disorder characterized by the development of plexiform neurofibromas (PNs), ...

[Emerging Targeted Therapies and Ongoing Clinical Trials in Pediatric Brain Tum…

Terashima(K) No Shinkei Geka 2025-11-00

...NF1-associated plexiform neurofibromas and shows promise for treating NF1-related low-grade gliomas. Tovorafenib, a type...

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