Artimani(T),Najafi(R) Cell Biol Int 2020-08-00

...APPL1 can prevent diabetes, endothelial disorders, and insulin resistance. In contrast, APPL1 deficiency can lead to the...

Lin(YY),Dong(LQ) Proc Jpn Acad Ser B Phys Biol… 2020-00-00

...Appl1 KO mice. Knockdown of Appl1 impaired adipogenesis in bone marrow-derived mesenchymal stem cells. Mineralization wa...

Mao(X),Kikani(CK),Riojas(RA),Langlais(P),Wan… Nat Cell Biol 2006-05-00

...APPL1 increases, and suppression of APPL1 level reduces, adiponectin signalling and adiponectin-mediated downstream even...

Prudente(S),Jungtrakoon(P),Marucci(A),Ludovi… Am J Hum Genet 2015-07-02

...APPL1 transfection. These findings-linking APPL1 mutations to familial forms of diabetes-reaffirm the critical role of A...

Ding(Y),Cao(Y),Wang(B),Wang(L),Zhang(Y),Zhan… PLoS One 2016-00-00

...APPL1 remains poorly understood. Here, we show that the protein levels and phosphorylation statues of APPL1were highly e...

Fan(L),Ye(H),Wan(Y),Qin(L),Zhu(L),Su(J),Zhu(… Metabolism 2019-00-00

...APPL1 in BAT thermogenesis. In this study, adipose tissue specific knockout (ASKO) mice were generated to evaluate APPL1...

Liu(R),Meng(J),Lou(D) Mol Med Rep 2021-10-00

...APPL1. Additionally, the release of HO‑11/HMGB1 was affected by adiponectin via AdipoR1/APPL1, and adiponectin/AdipoR1/A...

Shi(P),Tian(Y),Xu(F),Liu(LN),Wu(WH),Shi(YZ),… World J Diabetes 2024-02-15

...APPL1) plays a crucial role in regulating insulin signaling and glucose metabolism. Mutations in the APPL1 gene have bee...

Zhu(Q),Zhou(Y),Huang(Y),Chi(X) BMC Pregnancy Childbirth 2025-11-05

...APPL1, ADP and LEP on PE. (1) Prepregnancy BMI (22.15 ± 1.80 vs. 21.03 ± 1.99 kg/m2, p = 0.0028), APPL1 (82.65 ± 8.27 vs...

Guan(F),Ding(Y),He(Y),Li(L),Yang(X),Wang(C),… Korean J Physiol Pharmacol 2022-11-01

...APPL1 in DAT-induced cytotoxicity in HCC HepG2 cells. We found that Lys 63 (K63)-linked polyubiquitination of APPL1 was ...