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Breast cancer risk genes affecting individual radiosensitivity.

Vogel(RKG),Amann(N),Kassem(TZ),Gaß(P),Mayo... Sci Rep 2026-06-14

...BARD1, RAD51, and MSH variants suggested a possible increase (p < 0.003). Radiosensitivity was influenced by gene locus,...

Pharmacologic inhibition of RBBP4/p300-mediated homologous recombination acti...

Mapunda(JA),Laverty(DJ),Aziz(F),Le(A),Sang... Neurooncol Adv None

...BARD1, BRIP1, and FIGNL1), with RAD51 and BRIP1 correlating strongly with RBBP4 and p300. Silencing RBBP4 or p300 decrea...

53BP1-independent Shieldin-BRCA1 antagonism at replication-coupled double-str...

Feng(YL),Wang(M),Li(G),Chen(RD),Yao(R),Don... Nat Commun 2026-06-29

...Bard1-null cells retaining residual BRCA1, but not in cells expressing RING-less BRCA1 with degraded BARD1. These findin...

predNMD: prediction of nonsense-mediated mRNA decay for improved clinical var...

Su(Y),Brenner(SE) bioRxiv 2026-06-23

...BARD1 saturation genome-editing data, where RNA abundance reflects NMD. These results support replacing the 50nt rule in...

Breast cancer screening adherence after multigene panel testing among women w...

Comeaux(JG),Gutierrez(N),Ricker(CN),Nie(Q)... Breast Cancer Res Treat 2026-07-10

...BARD1, CHEK2, RAD51C, and RAD51D or with empiric lifetime risk ≥ 20%. We reviewed medical records of women without breas...

Real-world clinical outcomes, genetic testing patterns, and treatment pattern...

George(DJ),Kariburyo-Yay(F),Aggarwal(H),Te... Urol Oncol 2026-09-00

...BARD1, BRCA1, BRCA2, BRIP1, CDK12, CHEK1, CHEK2, FANCL, PALB2, RAD51B, RAD51C, RAD51D, and RAD54L. Biomarker testing pat...

Genomic Landscape of 6597 Hong Kong HBOC Patients: Implications for Beyond-BR...

Kwong(A),Ho(CYS),Tey(SK),Au(CH),Ma(ESK) Int J Mol Sci 2026-08-24

...BARD1. New cancers or recurrences were detected during their surveillance; the overall pick up rates were 8.3% (PALB2), ...

Comprehensive Genomic Profiling Reveals the Mutational Spectrum and Clinical ...

Ammous-Boukhris(N),Abdelmaksoud-Dammak(R),... Cancers (Basel) 2026-08-29

...BARD1, and BRIP1 (one case each). Furthermore, 56 VUS were identified; among them, 7 were prioritized based on in silico...

Mechanisms and disease relevance of DNA break repair pathway choice.

Swift(ML),Rogers(CM),Kaur(H),Chowdhury(D),... Nat Rev Mol Cell Biol 2026-09-18

...BARD1 and the 53BP1 axis in repair pathway choice. How RNA-DNA hybrids affect HR execution and how they are processed by...

Pathogenic BRCA1 Mutations Disrupt Allosteric Control by BARD1.

Bhattacharjee(A),Bowman(GR) J Phys Chem B 2025-08-07

...BARD1 selects for the active conformational states of BRCA1. We show that the helix bundle, where BARD1 binds, is allost...

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