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ATM promotes reversed fork processing during DNA interstrand cross-link repair.

Altshuller(M),MacKrell(VA),Tzeng(J),Nigam(R)… bioRxiv 2025-10-09

...EXO1 and DNA2 nucleases. Our data indicate that EXO1 initiates 5' to 3' resection of nascent lagging strands in the regr...

Targeting MMR-deficient colorectal cancer with a potent small molecule UNI110.

Amarsanaa(E),Oh(JM),Lee(SY),Maiti(S),Hong(SY… Anim Cells Syst (Seoul) 2025-00-00

...EXO1, thereby impairing long-range end resection during double-strand break (DSB) repair. These findings establish UNI11...

Arp2/3 and type-I myosins control chromosome mobility and end-resection at doub…

Zhou(FY),Ashton(M),Jiang(Y),Arora(N),Clark(K… Nat Commun 2025-08-05

...Exo1- and Dna2-dependent long-range resection reduces DSB mobility. Inactivating Arp2/3 before DSB induction leads to sh...

Asymmetrical recognition and processing of double-strand breaks formed during D…

Johnson(MJ),Kimble(MT),Jeong(S),Sane(A),Symi… bioRxiv 2025-07-05

...Exo1 or Dna2-Sgs1 long-range resection pathways. These findings indicate that resection proceeds differently at replicat...

Prime Editing Modification with FEN1 Improves F508del Variant Editing in the CF…

Volodina(OV),Demchenko(AG),Anuchina(AA),Ryzh… Int J Mol Sci 2025-08-18

...EXO1 and FEN1 nucleases to improve the original system. While all tested variants showed comparatively low efficiency in...

S-phase checkpoint protects from aberrant replication fork processing and degra…

Núñez-Martín(I),Drury(LS),Martínez-Jiménez(M… Nucleic Acids Res 2025-07-19

...Exo1, drive the gradual degradation of nascent DNA at replication forks upon DNA damage. Notably, this degradation can b...

DNA double-strand break end resection factors and WRN facilitate mitotic DNA sy…

Barwacz(SA),Lundgaard(K),Wu(W),Richter(PH),R… Nat Commun 2025-08-25

...EXO1 and BLM. Moreover, both the exonuclease and the helicase activities of WRN contribute to MiDAS. Because oncogene-in...

Cytosolic DNA and intracellular Ca2+: Maintaining genome stability during repli…

Li(S),Lu(HT),You(Z) DNA Repair (Amst) 2025-08-00

...EXO1 nuclease, thereby preventing aberrant fork processing and preserving chromosomal integrity. Separate from the ATR/C...

Integrating machine learning for the identification of ubiquitination-associate…

Niu(H),Wang(X),Zhou(Z),Liu(Y),He(S),Zhao(Y) Front Neurol 2025-00-00

...EXO1 and ISG15. Potential therapeutic drugs, including benzohydroxamic acid and PKC-beta inhibitors, were predicted to t...

Fmp45 promotes Rad53 dephosphorylation via Ptc2 interaction to attenuate checkp…

Cong(Z),Jiang(J),Li(M),Yan(C),Li(J),Zhang(X) J Genet Eng Biotechnol 2025-12-00

...Exo1) or NHEJ factor yku70. Laser confocal microscopy confirmed that FMP45 deletion did not impair nuclear localization ...

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