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The RRM domains of PARP14 mediate replication fork degradation in BRCA2-deficie…

Hale(A),Lynch(KA),Dhoonmoon(A),Nicolae(CM),M… NAR Cancer 2026-03-00

...MRE11 recruitment to reversed replication forks to promote their degradation. This results in genomic instability in BRC...

Cruciform-forming AT/TA repeats are acted upon by structure selective endonucle…

Boer(JL),Crippen(SM),Kim(AJ),Kramer(DN),Theu… bioRxiv 2026-01-22

...Mre11 nuclease and Rad51-dependent strand exchange occurs prior to repositioning. Replication analysis indicates that th...

Microhomology-mediated end joining acts directly on replication forks to repair…

Li(S),Zhao(Y),Li(Y),Shah(SB),Shi(Y),Nguyen(T… bioRxiv 2026-01-16

...MRE11/CtIP-mediated end resection, relies on RPA, and produces asymmetric deletion patterns, which is distinct from cano...

Expanding the mutational spectrum of RAD50: a case report of Nijmegen breakage …

Sun(H),Yang(B),Wang(F),Xie(R),Chen(T),Chen(X… Gene 2026-04-15

...MRE11-RAD50-NBS1 (MRN) complex involved in DNA double-strand break repair. Merely few cases have been reported worldwide...

ATM counteracts chromatin-bound cGAS during DNA replication.

Song(Y),Ran(X),Xu(Y),Subramanian(K),Dai(C),K… Nat Cell Biol 2026-05-00

...MRE11. ATR inhibition in ATM-deficient cells exacerbates replication stress, causing synthetic lethality and stimulated ...

Immediate protective effect of rUCMSC-EVs on ovarian function in a cyclophospha…

Yang(Z),Zou(C),Deng(Y),Xiao(H),Zou(Y),Wang(Z… J Ovarian Res 2026-04-29

...MRE11 and RAD51). Our study demonstrates that the combined intervention of rUCMSC-EVs and chemotherapy drugs can allevia...

Interaction of NDRG1 and MRE11 Modulates DNA Replication and Repair.

Doh(HM),Kozlova(N),Wang(ZA),Bae(H),Cole(PA),… Cancers (Basel) 2026-04-20

...MRE11) protein, a nuclease involved in DDR, as a putative NDRG1 interacting protein. Interaction between MRE11 and NDRG1...

A phosphorylation switch at MRE11 links ATM-ATR and calcium signaling to safegu…

Chai(WV),Ray(M),Chang(CC),Wang(ZG),Li(Z),Chi… Res Sq 2026-04-22

MRE11 safeguards genome stability at stalled replication forks, where its activity must be tightly controlled to prevent...

FeM-ID: a biotin labeling-based approach for the dissection of female meiotic c…

Feng(C),Wang(B),Cuacos(M),Lorenz(J),Hartmann… Plant Cell 2026-02-16

...mre11), and mutL homolog 3 (mlh3), facilitating cytological studies of heterochiasmy (sex-specific differences in recomb...

BRIP1-mediated RINT1 acetylation and NF-κB activation promote DNA repair and im…

Wu(H),Zhang(J),Yu(Y),Wang(W),Huang(J),Lin(Z)… Cancer Lett 2026-05-01

...MRE11-RAD50-NBS1 complex assembly, and augmenting HR-mediated DNA repair. Enhanced repair efficiency limits cytosolic DN...

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