...MSH2 and MLH1 predominated in Lynch syndrome-associated cases. TP53 (83%) and NF1 (51%) were frequent somatic co-alterat...
...MSH2, thereby impairing DNA damage repair capacity correlated positively with the expression of pivotal genes in these p...
...MSH2 deficiency. The remaining 26 non-hypermutated tumors had sparse mutation counts, limiting reliable signature interp...
...MSH2 when the recombining sequences contain mismatches. Given the repetitive nature of our genome, these findings highli...
...MSH2, and MSH6) was assessed to evaluate MSI status. Gonadotroph tumors were the most common subtype (45.5%). Statistica...
...MSH2 of MSH6 loss (9 of 91, 10%). Among the subset with MSI testing, MMRd by IHC and MSI were discordant in 16% (3 of 19...
...Msh2 with doxycycline-inducible expression of the proofreading-deficient PolεP286R mutant in murine small cell lung canc...
...MSH2, MSH6, PMS2) and confirmed by next-generation sequencing (NGS). Following disease progression on first-line gemcita...
...MSH2 (c.14C>A, p.Pro5Gln) with a variant allele frequency (VAF) of 48%, confirming the feasibility of CB as an alternati...
...MSH2 and MSH6 genomic deletions with ultrahigh TMB (>250 mutations/megabase) in whom pembrolizumab resulted in a strikin...
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