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Dampening DNA damage checkpoint signalling via coordinated BRCT domain interact…

Cussiol(José R),Jablonowski(Carolyn M),Yimit… EMBO J 2015-08-24

...Slx4-Rtt107 in checkpoint down-regulation. MBD mimics the damage-induced Dpb11-Slx4-Rtt107 complex by synergistically in...

The ERCC1 and ERCC4 (XPF) genes and gene products.

Manandhar(Mandira),Boulware(Karen S),Wood(Ri… Gene 2015-10-19

...SLX4 and TRF2 to perform its functions. Disruption of these interactions or direct targeting of ERCC1-XPF to decrease it...

Assembly of Slx4 signaling complexes behind DNA replication forks.

Balint(Attila),Kim(TaeHyung),Gallo(David),Cu… EMBO J 2015-10-28

...Slx4 complex formation is nucleated by Mec1 phosphorylation of histone H2A, which is recognized by the constitutive Slx4...

SLX4 contributes to telomere preservation and regulated processing of telomeric…

Sarkar(Jaya),Wan(Bingbing),Yin(Jinhu),Vallab… Nucleic Acids Res 2015-10-26

...SLX4 complex in telomere preservation. SLX4 associates with telomeres throughout the cell cycle, peaking in late S phase...

SUMOylation and PARylation cooperate to recruit and stabilize SLX4 at DNA damag…

González-Prieto(Román),Cuijpers(Sabine A G),… EMBO Rep 2015-12-21

...SLX4, mutating all of which abrogated the binding of SLX4 to SUMO-2 and covalent SLX4 SUMOylation. An SLX4 mutant lackin...

SLX4: not SIMply a nuclease scaffold?

Gibbs-Seymour(Ian),Mailand(Niels) Mol Cell 2015-04-06

...SLX4 DNA repair nuclease scaffold protein that promote its functions in genome stability maintenance pathways independen...

Noncovalent interactions with SUMO and ubiquitin orchestrate distinct functions…

Ouyang(Jian),Garner(Elizabeth),Hallet(Alexan… Mol Cell 2015-04-06

...SLX4 with ubiquitin are required for localizing SLX4 to DNA interstrand crosslinks (ICLs), yet how SLX4 is targeted to o...

The SLX4 complex is a SUMO E3 ligase that impacts on replication stress outcome…

Guervilly(Jean-Hugues),Takedachi(Arato),Naim… Mol Cell 2015-04-06

...SLX4 complex is a SUMO E3 ligase that SUMOylates SLX4 itself and the XPF subunit of the DNA repair/recombination XPF-ERC...

TopBP1 is required at mitosis to reduce transmission of DNA damage to G1 daught…

Pedersen(Rune Troelsgaard),Kruse(Thomas),Nil… J Cell Biol 2015-11-05

...SLX4 in mitosis. Persistent TopBP1 foci transition into 53BP1 nuclear bodies (NBs) in G1 and precise temporal depletion ...

The Slx4-Dpb11 scaffold complex: coordinating the response to replication fork …

Princz(Lissa N),Gritenaite(Dalia),Pfander(Bo… Cell Cycle 2015-12-01

...Slx4 and Dpb11 form a cell cycle kinase-dependent complex with the Mus81-Mms4 structure-selective endonuclease, which al...

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