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Postoperative Management After Risk-Reducing Salpingo-Oophorectomy for Heredi...

Ishida(H),Takashima(A) Cureus 2026-01-00

...BRCA1 and BRCA2 variants. RRSO has been shown to markedly reduce the risk of ovarian cancer and to confer a protective e...

Design and in silico characterization of a novel chimeric P53-SOG1 fusion pro...

Uzaif(Q) In Silico Pharmacol None

...BRCA1 (BRCT domain), and docked favorably with DNA (PDB ID: 1TUP), demonstrating that DNA-binding capability remained in...

Novel Insights into the Enigmatic Genetics of Male Breast Cancer in China.

Lang(GT),Weng(XL),Liu(Y),Hu(X),Shao(ZM),Hu(Z) Pathophysiology 2026-01-20

...BRCA1, BRCA2, and PALB2 variants, we delineated the genomic landscape of 96 MaBC cases. Subsequent whole-exome sequencin...

BRCA1/2, PALB2 mutations and first-line CDK4/6 inhibitor efficacy in HR+ meta...

Guinel(T),Lusque(A),Mailliez(A),Massard(V)... Breast 2026-04-00

...BRCA1/2 and PALB2 mutation carriers had reduced PFS with first-line ET + CDK4/6i compared to wild-type patients.

The Long and Winding Road toward Prevention of Estrogen Receptor-Negative and...

DeCensi(A),Lambertini(M) Cancer Prev Res (Phila) 2026-03-03

...BRCA1-associated disease. The study by Moyer and colleagues demonstrated that RXR agonists, particularly IRX4204, delay ...

Homologous recombination deficiency in high-grade serous ovarian carcinoma: c...

Ge(Y),He(Y),Yu(S),Gao(H),Sun(PL) J Gynecol Oncol 2026-07-00

...BRCA1/2 mutation and/or genomic scar score (GSS) ≥45. Correlations with clinicopathological variables, histological subt...

Risks of non-breast, non-ovarian cancers for BRCA1 and BRCA2 pathogenic varia...

Yang(R),MacInnis(RJ),Milne(RL),Nguyen-Dumo... BMC Med 2026-03-04

...BRCA1 PV carriers, there is no evidence that BRCA1 and BRCA2 PV carriers have substantially increased risks of other non...

Uterine tumors resembling ovarian sex cord tumors: rare case report and liter...

Pei(K),Xu(X),Li(Y),Long(Y),Xi(M),Duan(R) Front Oncol None

...BRCA1/2 or mismatch-repair genes, consistent with the fusion-negative UTROSCT subset (~30-45% of cases). At 20 months th...

Cancer metabolism in radiation sensitization - complementary roles of O-GlcNA...

Efimova(E),Liu(Y),Averbek(S),Choi(S),Ha(S)... J Cell Sci 2026-03-15

...BRCA1 and RAD51, and accumulation of cytosolic DNA in S/G2-phase cells. These effects were independent of PARP1 but requ...

AI-based BRAIx risk score for the intermediate-term prediction of breast canc...

Frazer(HML),Hopper(JL),Nguyen(TL),Elliott(... Lancet Digit Health 2026-04-00

...BRCA1 and BRCA2 mutations, could reveal insights into both familial and non-familial causes of breast cancer. Australian...

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