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Acetaldehyde stimulates FANCD2 monoubiquitination, H2AX phosphorylation, and BR…

Marietta(Cheryl),Thompson(Larry H),Lamerdin(… Mutat Res 2009-07-24

...BRCA1 phosphorylation at Ser1524 and increased the level of gammaH2AX, with both modifications occurring in a dose-depen...

Enhancing radiosensitivity: targeting the DNA repair pathways.

Jorgensen(Timothy J) Cancer Biol Ther 2009-08-04

...BRCA1 and 2 mutated breast cancer therapy is discussed, and future directions and challenges are explored.

The prevalence of BRCA1 mutations among young women with triple-negative breast…

Young(S R),Pilarski(Robert T),Donenberg(Tali… BMC Cancer 2009-06-24

...BRCA1 screening was performed using a combination of fluorescent multiplexed-PCR analysis, BRCA1 exon-13 6 kb duplicatio...

Breast cancer and aneusomy 17: implications for carcinogenesis and therapeutic …

Reinholz(Monica M),Bruzek(Amy K),Visscher(Da… Lancet Oncol 2009-03-25

...BRCA1 loss, and TOP2A amplification or deletion are known to have important roles in breast-cancer pathophysiology. Nume...

MERIT40 controls BRCA1-Rap80 complex integrity and recruitment to DNA double-st…

Shao(Genze),Patterson-Fortin(Jeffrey),Messic… Genes Dev 2009-05-08

Rap80 targets the breast cancer suppressor protein BRCA1 along with Abraxas and the BRCC36 deubiquitinating enzyme (DUB)...

MERIT40 facilitates BRCA1 localization and DNA damage repair.

Feng(Lin),Huang(Jun),Chen(Junjie) Genes Dev 2009-05-08

...BRCA1, plays pivotal roles in the maintenance of genomic integrity. Mounting evidence indicates that BRCA1 associates wi...

NBA1, a new player in the Brca1 A complex, is required for DNA damage resistanc…

Wang(Bin),Hurov(Kristen),Hofmann(Kay),Elledg… Genes Dev 2009-05-08

...BRCA1 A complex, which also contains Brca1/Bard1, Abra1, RAP80, BRCC36, and BRE. NBA1 is required to maintain BRE and Ab...

Familial breast cancer screening reveals an alteration in the RAP80 UIM domain …

Nikkilä(J),Coleman(K A),Morrissey(D),Pylkäs(… Oncogene 2009-05-05

...BRCA1-interacting protein, receptor associated protein 80 (RAP80), was identified. RAP80 plays an important role in BRCA...

Familial breast cancer: clinical response to induction chemotherapy or radiothe…

Fourquet(Alain),Stoppa-Lyonnet(Dominique),Ki… Am J Clin Oncol 2009-12-08

...BRCA1/2 mutation carriers were more responsive to induction treatments than in noncarriers.,The BRCA1 and BRCA2 genes we...

Customized treatment in non-small-cell lung cancer based on EGFR mutations and …

Rosell(Rafael),Perez-Roca(Laia),Sanchez(Jose… PLoS One 2009-07-07

...BRCA1 and could modulate the effect of BRCA1. In order to further examine the effect of EGFR mutations and BRCA1 mRNA le...

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