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Biology, metastatic patterns, and treatment of patients with triple-negative br…

Anders(Carey K),Carey(Lisa A) Clin Breast Cancer 2009-09-15

...BRCA1 mutation carriers develop breast cancer, it is usually basal-like; given the central role of BRCA1 in DNA repair, ...

Cost-effectiveness of population-based BRCA1/2 testing and ovarian cancer preve…

Rubinstein(Wendy S),Jiang(Hongmei),Dellefave… Genet Med 2009-11-13

About half of unaffected BRCA1/2 carriers have a negative family history, confounding efforts toward presymptomatic carr...

Timing of BRCA1/BRCA2 genetic testing in women with ovarian cancer.

Daniels(Molly S),Urbauer(Diana L),Stanley(Je… Genet Med 2009-11-13

...BRCA1/BRCA2 genetic testing.,Thirty-three percent of our sample (n = 100) were seen for genetic counseling after ovarian...

Genotyping of frequent BRCA1/2 SNPs with unlabeled probes: a supplement to HRMC…

De Leeneer(Kim),Coene(Ilse),Poppe(Bruce),De … J Mol Diagn 2009-11-03

We previously validated mutation scanning for BRCA1 and 2 using high-resolution melting curve analysis (HRMCA). Due to r...

Eleven years disease-free: role of chemotherapy in metastatic BRCA2-related bre…

Huang(Fleur),Kushner(Yael B),Langleben(Adria… Nat Rev Clin Oncol 2009-10-19

...BRCA1/2 mutation analysis.,A BRCA2 8765delAG mutation was identified, in the context of unusual and sustained complete r...

Clinical significance of epigenetic inactivation of hMLH1 and BRCA1 in Tunisian…

Karray-Chouayekh(Sondes),Trifa(Fatma),Khabir… J Biomed Biotechnol 2009-10-22

...BRCA1. BRCA1 methylation correlated with age at diagnosis (P = .015) and 5-years disease free survival (P = .016) while ...

Moderate increase in Mdr1a/1b expression causes in vivo resistance to doxorubic…

Pajic(Marina),Iyer(Jayasree K),Kersbergen(Ar… Cancer Res 2009-09-15

...BRCA1-related breast cancer was associated with increased expression of the mouse multidrug resistance (Mdr1) genes, whi...

Clinical and pathologic differences between BRCA1-, BRCA2-, and non-BRCA-associ…

Yip(Cheng-Har),Taib(N A),Choo(W Y),Rampal(S)… World J Surg 2009-12-11

...BRCA1, 15 BRCA2). We found that tumors in BRCA1 carriers were more likely to be estrogen receptor (ER)-negative and prog...

Targeting the molecular defect in BRCA-deficient tumors for cancer therapy.

Venkitaraman(Ashok R) Cancer Cell 2009-08-21

...BRCA1 or BRCA2 genes exemplifies this promising new trend.

Aberrant luminal progenitors as the candidate target population for basal tumor…

Lim(Elgene),Vaillant(François),Wu(Di),Forres… Nat Med 2009-08-25

...BRCA1 gene, encoding the tumor suppressor protein BRCA1, are thought to develop from the mammary stem cell. To explore e...

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