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DNA damage response pathways in tumor suppression and cancer treatment.

Liang(Yulong),Lin(Shiaw-Yih),Brunicardi(F Ch… World J Surg 2009-07-16

...BRCA1/2 mutations. Since Brit1 is a key regulator in DDR and HR repair, we believe that we can develop a similar strateg...

Family history of breast cancer and all-cause mortality after breast cancer dia…

Chang(Ellen T),Milne(Roger L),Phillips(Kelly… Breast Cancer Res Treat 2009-11-17

...BRCA1 or BRCA2 were excluded. Cases and their relatives completed structured questionnaires assessing breast cancer risk...

The DNA repair proteins BRCA1 and ERCC1 as predictive markers in sporadic ovari…

Weberpals(Johanne),Garbuio(Kyla),O'Brien(Ann… Int J Cancer 2009-01-14

...BRCA1 vs. higher BRCA1 (46 vs.33 months, p = 0.03). High BRCA1 was predictive of poorer OS specifically in patients with...

Time to stop ovarian cancer screening in BRCA1/2 mutation carriers?

van der Velde(Nienke M),Mourits(Marian J E),… Int J Cancer 2009-01-14

...BRCA1/2 mutation. We evaluated 241 consecutive women with a BRCA1 or BRCA2 mutation who were enrolled in the surveillanc...

Growth and molecular interactions of the anti-EGFR antibody cetuximab and the D…

Oliveras-Ferraros(Cristina),Vazquez-Martin(A… Int J Oncol 2009-02-02

...BRCA1. Concurrent treatment with sub-optimal doses of cetuximab significantly enhanced CDDP-induced apoptotic cell death...

The structure of Fcp1, an essential RNA polymerase II CTD phosphatase.

Ghosh(Agnidipta),Shuman(Stewart),Lima(Christ… Mol Cell 2009-01-15

...BRCA1 C-terminal (BRCT) domain. The structure and mutational analysis reveals that Fcp1 and Scp1 (a Ser5-selective phosp...

Can genetic testing guide treatment in breast cancer?

Tutt(Andrew),Ashworth(Alan) Eur J Cancer 2009-01-22

...BRCA1 or BRCA2 mutation? In this review, we consider whether BRCA1 or BRCA2 mutation influences the choice of breast scr...

Hereditary breast cancer syndromes and clinical implications.

Majdak-Paredes(E J),Fatah(F) J Plast Reconstr Aesthet Surg 2009-03-04

...BRCA1/2 genes and the high-risk patients for developing breast cancer would allow a better understanding of the natural ...

Occult fallopian tube cancer in a patient with BRCA1 breast cancer.

Brown(John V),Epstein(Howard D),Mattison(Jul… J Minim Invasive Gynecol 2009-02-19

...BRCA1 or -2 mutation may be more vulnerable to developing this disease. A patient with breast carcinoma was initially tr...

Expression profile of BRCA1 and BRCA2 genes in premenopausal Mexican women with…

Loredo-Pozos(Gloria),Chiquete(Erwin),Oceguer… Med Oncol 2009-11-25

...BRCA1 expression than older women (P < 0.05). BRCA1 and BRCA2 expression correlated in healthy, but not in tumor tissues...

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