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Targeted Prostate Cancer Screening in Carriers of BRCA1 or BRCA2 Pathogenic G...

Bancroft(EK),Page(EC),McHugh(J),Thomas(S),... Eur Urol 2026-05-00

...BRCA1/BRCA2 PGV carriers (915 BRCA1, 901 BRCA2); and (2) age-matched noncarriers for a familial PGV (727 BRCA1 and 520 B...

Expanding the therapeutic applications of PARP inhibitors in cancer by target...

Jafari(A),Fathi(S),Moosavi(F),Firuzi(O) Biochim Biophys Acta Rev Ca... 2026-07-00

...BRCA1/2 mutations. However, their clinical utility is mainly restricted to HRD tumors and also hindered by innate or acq...

FASN Inhibition Enhances the Efficacy of Chemotherapy in Colorectal Cancer by...

Banerjee(M),Zaytseva(YY),Reusch(EM),Napier... Cancer Res 2026-05-15

...BRCA1 and ATM recruitment to γH2AX foci in an acetylation-dependent manner. Moreover, FASN inhibition-mediated DNA repai...

Multi-target modulation of the homologous recombination pathway by resveratro...

Yu(Z),Peng(W),Li(M),Li(F),Zhang(T),Nong(Y)... Int J Surg 2026-02-05

...BRCA1, and RAD51 - significantly enriched in the HR pathway. Molecular docking and dynamic simulations indicate that RSV...

Unique perspectives about men's awareness of BRCA1/2 genetic testing in prima...

Andrews(CS),Ibrahim(I),Baruch(YB),Zisk-Ron... Sci Rep 2026-02-11

...BRCA1/2 status, largely due to not knowing what BRCA1/2 was. While 52% perceived prostate cancer as a high-risk conditio...

Age-stratified analysis of invasive lobular carcinoma reveals comparable clin...

Uchida(S) Discov Oncol 2026-02-18

...BRCA1 and CASP8 mutations, while copy number alterations in FGF4, FGF19 and CCND1 increased progressively with age. CONC...

Diagnostic plasma protein signatures in sporadic and BRCA1/2 breast cancer pa...

Holm(KY),Mohammed(Y),Gunnarsdottir Thormar... Breast Cancer Res 2026-07-18

...BRCA1/2 (n = 47) and triple-negative (n = 17) patients than in paired controls. IGHM and CD5L were also lower in BRCA1/2...

Transforming Breast Cancer Control in East Africa by Integrating Cytomorpholo...

Rioki(JN),Joseph(M),Lel(R),Mweu(M),Muchiri(L) Cureus 2026-06-00

...BRCA1/2 mutations, this perspective argues for a fundamental shift in national health policy. We propose that the curren...

Research on the impact of different chemotherapy and targeted therapy regimen...

Ruan(G),Li(D),Miao(B) Pak J Pharm Sci 2026-10-00

...BRCA1/2 mutations both significantly improved DFS (p<0.05). Multivariate analysis confirmed TNBC, positive lymph node me...

Structural Modification and Prodrug Design Based on Natural Stilbene Scaffold...

Zou(Z),Lu(G),Xin(M),Du(Z),Cheng(Z),Wu(S),C... J Med Chem 2026-08-13

...BRCA1-deficient cell lines (SUM149PT, MDA-MB-436, and HCC1937) and the BRCA2-deficient cell line (Capan-1). Mechanistic ...

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