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Genetic variant of C1GalT1 contributes to the susceptibility to IgA nephropathy.

Pirulli(Doroti),Crovella(Sergio),Ulivi(Sheil… J Nephrol 2009-06-04

...C1GalT1). To evaluate the association between C1GalT1 single nucleotide polymorphisms (SNPs) and IgAN, we performed a ca...

No evidence for a role of cosmc-chaperone mutations in European IgA nephropathy…

Malycha(Friederike),Eggermann(Thomas),Hristo… Nephrol Dial Transplant 2009-02-27

...C1GALT1) and its chaperone cosmc are specifically required for O-galactosylation of the IgA1 hinge region. Mutations in ...

Endothelial cell O-glycan deficiency causes blood/lymphatic misconnections and …

Fu(Jianxin),Gerhardt(Holger),McDaniel(J Mich… J Clin Invest 2009-01-12

...C1galt1 that is critical for the biosynthesis of core 1-derived O-glycans, in ECs and hematopoietic cells (termed here E...

Interaction between variants of two glycosyltransferase genes in IgA nephropath…

Zhu(Li),Tang(Wanwan),Li(Guisen),Lv(Jicheng),… Kidney Int 2009-09-09

...C1GALT1 and ST6GALNAC2, were associated with susceptibility to IgAN. Here we measured the genetic interaction of variant...

Association of cell surface mucins with galectin-3 contributes to the ocular su…

Argüeso(Pablo),Guzman-Aranguez(Ana),Mantelli… J Biol Chem 2009-10-06

...c1galt1 (T-synthase), a critical galactosyltransferase required for the synthesis of core 1 O-glycans, resulted in decre...

Pathogenetic significance of aberrant glycosylation of IgA1 in IgA nephropathy.

Narita(Ichiei),Gejyo(Fumitake) Clin Exp Nephrol 2008-11-25

...C1GALT1, have been reported to be responsible for susceptibility to IgAN, recent evidence suggests that the abnormality ...

The genetic susceptibility to IgA nephropathy: a novel functional candidate gen…

Narita(I),Kaneko(Y),Kondo(D),Goto(S),Sakatsu… Kidney Int 2007-04-12

...C1GALT1, may be responsible for susceptibility to IgA nephropathy.

Variants of C1GALT1 gene are associated with the genetic susceptibility to IgA …

Li(G-S),Zhang(H),Lv(J-C),Shen(Y),Wang(H-Y) Kidney Int 2007-04-12

...C1GALT1 and C1GALT1C1 genes and the susceptibility to IgAN. A total of 1164 subjects were enrolled, including 670 IgAN p...

Thrombocytopenia and kidney disease in mice with a mutation in the C1galt1 gene.

Alexander(Warren S),Viney(Elizabeth M),Zhang… Proc Natl Acad Sci U S A 2006-12-22

...C1GalT1, appropriate glycosylation of which is essential for platelet production and kidney function. Compromised C1GalT...

Peripheral B lymphocyte beta1,3-galactosyltransferase and chaperone expression …

Qin(W),Zhou(Q),Yang(L-C),Li(Z),Su(B-H),Luo(H… J Intern Med 2005-11-14

...C1GALT1) and its chaperone (Cosmc) in IgAN, and their relationships with clinical features as well as IgA glycosylation ...

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