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Catalytic inhibition of topoisomerase II by a novel rationally designed ATP-com…

Chène(Patrick),Rudloff(Joëlle),Schoepfer(Jos… BMC Chem Biol 2009-12-11

...BRCA1 mutant breast cancer cells have increased sensitivity to QAP 1.,The results obtained with QAP 1 demonstrate that p...

Comparative clinical and transcriptomal profiles of breast cancer between Frenc…

Chalabi(N),Bernard-Gallon(D J),Bignon(Y J),,… Cancer Genomics Proteomics 2009-02-06

...BRCA1, TFAP2C, GJA1 and TFF1 were also found. Additionally, an up-regulation of cytokeratins KRT8 and KRT18 may indicate...

Hereditary breast and ovarian cancer syndrome : the impact of race on uptake of…

Simon(Michael S),Petrucelli(Nancie) Methods Mol Biol 2009-03-19

...BRCA1 and BRCA2 mutations in the AA and African population with the possible identification of African founder mutations...

[Inactivation of BRCA1, BRCA2 and p53 genes in sporadic ovarian cancer].

Zikán(M),Pohlreich(P),Freitag(P),Janousek(M)… Ceska Gynekol 2009-01-27

To analyze loss of heterozygosity (LOH), loss of expression and somatic mutations of BRCA1, BRCA2 and p53 genes in spora...

Breast cancer and ovarian cancer genetics: an update.

Edlich(Richard F),Cross(Catherine L),Wack(Co… J Environ Pathol Toxicol Oncol 2009-01-13

...BRCA1/2 genes. We also discuss in more detail the unique psychological ramifications of female BRCA1/2 mutation carriers...

Pharmacogenomics of gemcitabine in non-small-cell lung cancer and other solid t…

Danesi(Romano),Altavilla(Giuseppe),Giovannet… Pharmacogenomics 2009-03-23

...BRCA1 and ERCC1. Hopefully, biomarkers to select patients most likely to respond to gemcitabine will be validated in the...

Downregulation of EZH2 decreases growth of estrogen receptor-negative invasive …

Gonzalez(M E),Li(X),Toy(K),DuPrie(M),Ventura… Oncogene 2009-03-30

...BRCA1 protein. Of note, BRCA1 knockdown was sufficient to rescue the effects of EZH2 downregulation on proliferation, G(...

MYC in breast tumor progression.

Chen(Yinghua),Olopade(Olufunmilayo I) Expert Rev Anticancer Ther 2009-02-12

...BRCA1 is linked to transcriptional regulation through interaction with MYC. Although the relationship between amplificat...

Regulation of centrosomes by the BRCA1-dependent ubiquitin ligase.

Kais(Zeina),Parvin(Jeffrey D) Cancer Biol Ther 2009-03-18

...BRCA1. This review will focus on the importance of controlling centrosome number and on the effect of BRCA1 on the centr...

Prevalence and characteristics of pancreatic cancer in families with BRCA1 and …

Kim(Daniel H),Crawford(Beth),Ziegler(John),B… Fam Cancer 2009-09-25

...BRCA1 and 17/156 (10.9%) BRCA2 families had at least 1 individual with pancreatic cancer. In the 24 BRCA1 families, medi...

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