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YTHDF3 facilitates DNA damage response by recognizing METTL3-mediated m6A mod...

Cheng(M),Pang(Y),Wang(R),Chen(X),Zhang(C),... Cancer Lett 2026-07-01

...BRCA1, RAD51, RIF1 and 53BP1) and promotes their translation through m6A methylation, thereby initiating homologous reco...

A comprehensive and accessible model for co-segregation analysis in BRCA1, BR...

Moghadasi(S),Monajemi(R),Braspenning(ME),V... Hum Genet 2026-03-26

...BRCA1, BRCA2 and PALB2 genes, which can be used as an important component of the ACMG/AMP (the American College of Medic...

Pembrolizumab and olaparib in homologous-recombination-deficient metastatic p...

Park(W),O'Connor(CA),Chou(JF),Hilmi(M),Tar... Nat Med 2026-05-00

Homologous recombination deficiency (HRD) arising from BRCA1or BRCA2 or PALB2 mutations confers sensitivity to platinum ...

Genomic profiling in Bulgarian women with ovarian cancer: a dual-sample NGS a...

Kamburova(Z),Popovska(S),Tsvetkov(C) Hered Cancer Clin Pract 2026-03-25

...BRCA1 (3/33; 9.1%), with single cases in ATM, RAD51D, NBN, FANCL and WRN. One patient fulfilled criteria for multi‑locus...

An intriguing journey into the hereditary syndromes predisposing to endometri...

Fanale(D),Magrin(L),Corsini(LR),Pedone(E),... Ther Adv Med Oncol None

...BRCA1/2, MUTYH, NTHL1, STK11, which confer an increased risk of developing an early onset EC. Lynch syndrome is the main...

BAP1 dysregulation impairs trophoblast differentiation and contributes to pla...

Doria-Borrell(P),Ferrero-Micó(A),Navarro-S... Cell Death Dis 2026-03-26

...BRCA1-associated protein 1 (BAP1) and its cofactors ASXL2 and ASXL3 as upregulated in EO-PE placentas. Enforced BAP1 exp...

CBX2 phase-separation contributes to homologous recombination repair and drug...

Sun(S),Huang(L),Ma(Y),Wei(Z),Zhu(M),Chen(M... Cell Death Dis 2026-03-26

...BRCA1 to chromatin. Patients with a CBX2-negative pattern exhibit the best prognosis, followed by those with non-condens...

PI3K/Akt/mTOR pathway expression profiling reveals age- and subtype-specific ...

Udobi(ME),Chinedu(SN),Afolabi(IS),Ezike(KN... Front Oncol None

...BRCA1 and BRCA2, alongside luminal regulators like GATA3, decline progressively with both advancing age and tumor aggres...

The BRCA1-A complex restricts replication fork reversal-dependent DNA repair ...

Datta(A),Jackson(J),Morozov(YI),Qiu(J),Vin... bioRxiv 2026-03-22

...BRCA1-A damaged fork recognition to restrict end-resection and cause Topoisomerase I inhibitor hypersensitivity. BRCA1-A...

Re-evaluating hereditary breast and ovarian cancer risk: clinical impact of u...

Gislinge(JIP),Byrjalsen(A),Naver(KV),Claus... Fam Cancer 2026-03-27

...BRCA1/2 have been identified, highlighting the need for updated genetic evaluation in women previously classified as hig...

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