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Dencker(C),Strehlow(V),Aktas(B),Lemke(J),H... Hered Cancer Clin Pract 2026-03-12

...BRCA1, which also increases ovarian cancer risk and, in men, prostate cancer risk. BRCA1 variants are typically autosoma...

Kawahara(S),Taki(M),Hamanishi(J),Ebara(S),... Mol Cancer Ther 2026-03-12

...BRCA1 and BRCA2, induced apoptosis and DNA damage, and inhibited tumor growth in USC PDX models with high CDK12 expressi...

Saule(C),Laas(E),Weber(N),Bataillon(G),Bec... Gynecol Oncol 2026-05-00

Women with inherited susceptibility or a strong family history of ovarian cancer, particularly carriers of pathogenic BR...

Nahshon(C),Assaf(W),Fahoum(L),Regev-Sadeh(... Maturitas 2026-05-00

...BRCA1/2 pathogenic variant who had previously undergone risk-reducing salpingo-oophorectomy with or without concomitant ...

Laitman(Y),Zalmanoviz(S),Netzer(I),Bernste... Cancer Genet 2026-06-00

...BRCA1, BRCA2, MSH2, and MSH6 genes, has not been reported. Individuals who underwent MGPT after oncogenetic counseling b...

Hu(L),Ma(X),Cai(X),Yan(T),Zhou(K),Shan(C),... Cell Discov 2026-03-12

BRCA1-deficient epithelial ovarian cancer (EOC) is reported to respond to poly (adenosine diphosphate-ribose) polymerase...

Murata-Kamiya(N),Del Valle Lazarte(AA),Kik... Sci Rep 2026-03-12

...BRCA1, which promotes its nuclear translocation. In the nucleus, BRCA1 protects stalled replication forks and repairs do...

Fang(P),Saunders(A),Minn(K),Chua(KJ),Brook... NPJ Precis Oncol 2026-03-12

...BRCA1/2 and RAD51 paralogs, suggesting a shared HR program. Functionally, transient knockdown of FOXM1 or MYC reduced BR...

Khan(NU),Lei(H),Fu(J),Lei(R),Chen(X),Alqar... J Transl Med 2026-03-12

BACKGROUND: The breast cancer (BC) susceptibility genes 1 (BRCA1) and BC susceptibility genes 2 (BRCA2) are critical gen...

Hawsawi(YM),Mansoor(I),Sayan(M),Alsaleem(M... Int J Surg Pathol 2026-08-00

...BRCA1 and BRCA2. To clarify the clinicopathological impact of somatic PALB2 variants, we analyzed tumor DNA extracted fr...