...BRCA1)- and breast cancer susceptibility type 2 (BRCA2)-mutant tumors, impaired RAD51 loading produces profound sensitiv...
...BRCA1/2 mutation, and Nottingham prognostic index (NPI), while negatively correlated with age, ER status, and PR status....
...BRCA1/2-dependent manner, with RAD51 loading onto viral DNA immediately during reverse transcription. Using ChIP, imagin...
...BRCA1, we identified 16 rare pathogenic variants in strong linkage disequilibrium undergoing purifying selection that co...
...BRCA1 and BRCA2 genes may provide meaningful clinical interpretation of BC risk. Exons 4 and 16 of BRCA1 and exons 18, 2...
...BRCA1;p53-deficient mouse mammary tumours and human clinical samples. By integrating single-cell RNA sequencing, spatial...
...BRCA1 and BRCA2, GenixRL achieved the best performance and ranked highest on 14 of 17 clinically significant genes in a ...
...BRCA1, TP53, ESR1, ERBB2, PIK3CA, etc.), and a composite Gene Mutation Score (GMS) were analyzed. Multivariate logistic ...
...BRCA1/2 and CHEK2) were observed in 10% of patients, some of whom had a family history of cancer. This highlights the im...
...BRCA1, 3 CHEK2, 2 TP53, 1 BRCA2, 1 BRIP1, and 1 PALB2). Additionally, one individual harbored a monoallelic PV in MUTYH....
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