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Dual-fluorophore quantitative high-throughput screen for inhibitors of BRCT-pho…

Simeonov(Anton),Yasgar(Adam),Jadhav(Ajit),Lo… Anal Biochem 2008-05-01

...BRCA1, a key tumor suppressor protein with various functions) and phosphorylated proteins (Abraxas/BACH1/CtIP), implicat...

Prevalence of pathogenic BRCA1 mutation carriers in 5 US racial/ethnic groups.

John(Esther M),Miron(Alexander),Gong(Gail),P… JAMA 2008-01-07

...BRCA1 mutation carriers in racial/ethnic minority populations is limited.,To estimate BRCA1 carrier prevalence in Hispan...

BRCA1 p.Val1688del is a deleterious mutation that recurs in breast and ovarian …

Malacrida(Sandro),Agata(Simona),Callegaro(Mo… J Clin Oncol 2008-01-29

A growing number of sequence changes of unknown clinical significance are being identified in the BRCA1 gene. However, t...

Increased uptake of BRCA1/2 genetic testing among African American women with a…

Susswein(Lisa R),Skrzynia(Cécile),Lange(Lesl… J Clin Oncol 2008-01-29

Studies suggest that African American women are less likely to pursue BRCA1/2 genetic testing than white women. However,...

Effect of BRCA1/2 mutations on long-term survival of patients with invasive ova…

Chetrit(Angela),Hirsh-Yechezkel(Galit),Ben-D… J Clin Oncol 2008-01-29

...BRCA1 and BRCA2 carriers compared with noncarriers. During the study period (median follow-up, 6.2 years), being a BRCA1...

Breast cancers detected with imaging screening in the BRCA population: emphasis…

Causer(Petrina A),Jong(Roberta A),Warner(Ell… Radiographics 2008-04-02

...BRCA1 or BRCA2 gene, has been established in numerous studies and is now becoming part of routine clinical practice. Des...

Similar prevalence of founder BRCA1 and BRCA2 mutations among Ashkenazi and non…

Chodick(Gabriel),Struewing(Jeffery P),Ron(El… Eur J Med Genet 2008-06-24

...BRCA1 185delAG mutations were found. Similar frequencies of BRCA1 and BRCA2 mutation carriers were found among Ashkenazi...

BRCA1-mediated ubiquitination inhibits topoisomerase II alpha activity in respo…

Shinagawa(Hirokuni),Miki(Yoshio),Yoshida(Kiy… Antioxid Redox Signal 2008-05-19

...BRCA1, a tumor-suppressor gene, appeared to be involved in these alterations in topoisomerase IIalpha. Furthermore, the ...

Distinct genomic aberration patterns are found in familial breast cancer associ…

Melchor(L),Honrado(E),García(M J),Alvarez(S)… Oncogene 2008-06-03

...BRCA1, 16 BRCA2 and 28 non-BRCA1/2), with the same panel of 25 immunohistochemical (IHC) markers and histological grade ...

Concerted transcriptional regulation by BRCA1 and COBRA1 in breast cancer cells.

Aiyar(Sarah E),Cho(HyungJun),Lee(Jae),Li(Ron… Int J Biol Sci 2008-02-29

...BRCA1 (COBRA1) was first identified as a protein that binds to the breast cancer susceptibility gene product BRCA1. COBR...

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