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Cancer stem cells contribute to cisplatin resistance in Brca1/p53-mediated mous…

Shafee(Norazizah),Smith(Christopher R),Wei(S… Cancer Res 2008-06-10

The majority of BRCA1-associated breast cancers are basal cell-like, which is associated with a poor outcome. Using a sp...

Histopathological features of 'BRCAX' familial breast cancers in the kConFab re…

Loughrey(Maurice),Provan(Pamela J),Byth(Kare… Pathology 2008-08-06

...BRCA1 mutation carriers. In BRCAX families, BRCA1 tumour phenotype may signal the presence of an unidentified BRCA1 muta...

Complementary and alternative medicine use among women at increased genetic ris…

Mueller(Christine M),Mai(Phuong L),Bucher(Ja… BMC Complement Altern Med 2008-06-20

...BRCA1 or BRCA2 mutation-positive (BRCA+) women in this analysis, 78% reported CAM use, with prayer and lifestyle diet be...

Structural evidence for direct interactions between the BRCT domains of human B…

Shen(Yang),Tong(Liang) Biochemistry 2008-06-10

...BRCA1 C-terminal (BRCT) domains are phospho-serine/threonine recognition modules essential for the function of BRCA1. Re...

Molecular analysis-based treatment strategies for non-small cell lung cancer.

Bepler(Gerold),Begum(Mubeena),Simon(George R) Cancer Control 2008-08-26

...BRCA1, which are involved in nucleotide metabolism and DNA damage repair, epidermal growth factor receptor, which is inv...

Human U2 snRNA genes exhibit a persistently open transcriptional state and prom…

Pavelitz(Thomas),Bailey(Arnold D),Elco(Chris… Mol Cell Biol 2008-06-16

...BRCA1, or BRCA2 function, treatment with actinomycin D, or overexpression of the tetrameric p53 C terminus. We propose t...

Expression of BRCA1 protein in breast cancer and its prognostic significance.

Rakha(Emad A),El-Sheikh(Somaia E),Kandil(Mon… Hum Pathol 2008-07-01

...BRCA1 was an independent predictor of disease-free interval. BRCA1 alteration may play a significant role in the develop...

Common breast cancer-predisposition alleles are associated with breast cancer r…

Antoniou(Antonis C),Spurdle(Amanda B),Siniln… Am J Hum Genet 2008-05-13

...BRCA1 carriers. rs3803662 was associated with increased breast cancer risk in both BRCA1 and BRCA2 mutation carriers (pe...

Hereditary breast cancer: from molecular pathology to tailored therapies.

Tan(D S P),Marchiò(C),Reis-Filho(J S) J Clin Pathol 2008-10-21

...BRCA1 and BRCA2, are responsible for about 16% of the familial risk of breast cancer. Even though subsequent studies hav...

What women with ovarian cancer think and know about genetic testing.

Lacour(Robin A),Daniels(Molly S),Westin(Shan… Gynecol Oncol 2008-10-23

...BRCA1 and BRCA2. With the prospect of BRCA-directed therapeutics, we investigated ovarian cancer patients' knowledge and...

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