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Secondary BRCA1 and BRCA2 alterations and acquired chemoresistance.

Wang(Weixin),Figg(William D) Cancer Biol Ther 2008-11-18

...BRCA1 or BRCA2 (BRCA1/2) mutations. Cancers that arise in mutation carriers have often lost the wild-type allele through...

Carrier-resolved technology for homogeneous and multiplexed DNA assays in a 'on…

Li(Huan),Lau(Choiwan),Lu(Jianzhong) Analyst 2008-12-05

...BRCA1) and showed high selectivity and attomolar-femtomolar sensitivity. The mixture of three different capture probe co...

BRCA1 overexpression sensitizes cancer cells to lovastatin via regulation of cy…

Yu(Xiaoping),Luo(Yuanqiong),Zhou(Yong),Zhang… Int J Oncol 2008-10-07

...BRCA1 allele, were transfected with pcDNA3-beta-HA-hsBRCA1 plasmids via liposomes to reconstitute BRCA1 overexpression h...

BAT3 and SET1A form a complex with CTCFL/BORIS to modulate H3K4 histone dimethy…

Nguyen(Phuongmai),Bar-Sela(Gil),Sun(Lunching… Mol Cell Biol 2008-11-07

...BRCA1. RNA interference (RNAi) knockdown of BAT3, as well as SET1A, decreased Myc and BRCA1 gene expression but did not ...

Glucose-regulated protein 78 as a novel effector of BRCA1 for inhibiting stress…

Yeung(B H Y),Kwan(B W Y),He(Q Y),Lee(A S),Li… Oncogene 2008-12-10

...BRCA1 suppressed the expression of GRP78, whereas expression of mutant BRCA1 gene or targeted inhibition of endogenous B...

Germline BRCA1 mutations predispose to pancreatic adenocarcinoma.

Al-Sukhni(Wigdan),Rothenmund(Heidi),Borgida(… Hum Genet 2008-10-24

...BRCA1 mutations is less clear. We hypothesized that the loss of heterozygosity at the BRCA1 locus occurs in pancreatic c...

NBS1 prevents chromatid-type aberrations through ATM-dependent interactions wit…

Antoccia(A),Sakamoto(S),Matsuura(S),Tauchi(H… Radiat Res 2008-10-16

...BRCA1 is required for the interaction of NBS1 with SMC1, whereas the reverse is not the case, since BRCA1 is able to bin...

BRCA1-associated protein-1 is a tumor suppressor that requires deubiquitinating…

Ventii(Karen H),Devi(Narra S),Friedrich(Kenn… Cancer Res 2008-09-18

BRCA1-associated protein-1 (BAP1), a deubiquitinating enzyme of unknown cellular function, is mutated in breast and lung...

ATM acts downstream of ATR in the DNA damage response signaling of bystander ce…

Burdak-Rothkamm(Susanne),Rothkamm(Kai),Prise… Cancer Res 2008-09-18

...BRCA1 foci in nontargeted cells was shown, suggesting their involvement in bystander DNA damage signaling and providing ...

Discovering interactions among BRCA1 and other candidate genes associated with …

Lo(Shaw-Hwa),Chernoff(Herman),Cong(Lei),Ding… Proc Natl Acad Sci U S A 2008-10-24

...BRCA1 plays a dominant and central role. The apparent interactions of BRCA1 with many other genes suggests the conjectur...

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