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Expression and localization of Werner syndrome protein is modulated by SIRT1 an…

Vaitiekunaite(Rasa),Butkiewicz(Dorota),Krześ… Mech Ageing Dev 2008-03-06

...BRCA1 foci. Our data indicate for the first time that SIRT1 protein may be functionally associated with WRN and BLM heli...

Enhancement of radiation response by inhibition of Aurora-A kinase using siRNA …

Tao(Y),Zhang(P),Frascogna(V),Lecluse(Y),Aupe… Br J Cancer 2008-02-14

...Brca1 foci formation only in cells with deficient p53. However, the drug brought about additive to sub-additive interact...

[Molecular genetics and clinics of hereditary breast cancer].

Schmutzler(R K) Verh Dtsch Ges Pathol 2008-01-25

...BRCA1 and BRCA2, have been identified and account for a risk of up to 80% for breast cancer and up to 40% for ovarian ca...

[Molecular carcinogenesis of ovarian carcinoma].

Diebold(J) Verh Dtsch Ges Pathol 2008-01-25

...BRCA1/2 and TP53 mutations. The pattern of molecular aberrations of carcinosarcomas (Malignant müllerian mixed tumours) ...

Identification of BRCA1 missense substitutions that confer partial functional a…

Lovelock(Paul K),Spurdle(Amanda B),Mok(Myth … Breast Cancer Res 2008-03-06

Many of the DNA sequence variants identified in the breast cancer susceptibility gene BRCA1 remain unclassified in terms...

Breast cancer risk associated with BRCA1 and BRCA2 in diverse populations.

Fackenthal(James D),Olopade(Olufunmilayo I) Nat Rev Cancer 2008-01-03

...BRCA1 or BRCA2 tumour-suppressor genes are strong predictors of breast and/or ovarian cancer development. The contributi...

Brca1 in immunoglobulin gene conversion and somatic hypermutation.

Longerich(Simonne),Orelli(Brian J),Martin(Ri… DNA Repair (Amst) 2008-05-13

...Brca1 confer susceptibility to breast cancer and genomic instability indicative of aberrant repair of DNA breaks. Brca1 ...

Genetic polymorphisms and micronucleus formation: a review of the literature.

Iarmarcovai(G),Bonassi(S),Botta(A),Baan(R A)… Mutat Res 2008-07-31

...BRCA1 and BRCA2 mutations (with or without breast cancer) show enhanced sensitivity to clastogens. Some evidence further...

SUMO1 negatively regulates BRCA1-mediated transcription, via modulation of prom…

Park(Mi Ae),Seok(Yeong-Jae),Jeong(Gajin),Lee… Nucleic Acids Res 2008-02-15

...BRCA1 and release of HDAC1 at the BRCA1 target promoters, and subsequent transcriptional activation of the BRCA1 target ...

Negative selection on BRCA1 susceptibility alleles sheds light on the populatio…

Pavard(Samuel),Metcalf(C Jessica E) PLoS One 2008-08-21

...BRCA1-carriers into population genetics frameworks, and calculate selection coefficients on BRCA1 alleles for different ...

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