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Intrinsically disordered proteins in human diseases: introducing the D2 concept.

Uversky(Vladimir N),Oldfield(Christopher J),… Annu Rev Biophys 2008-08-01

...BRCA1, are attractive targets for drugs modulating protein-protein interactions. From these and other examples, novel st...

[Prophylactic mastectomy in women at high risk for breast cancer: indications a…

Scheufler(O),Fritschen(U von) Handchir Mikrochir Plast Chir 2008-11-18

...BRCA1/2 mutation carriers with hereditary breast and ovarian cancer, bilateral prophylactic ovarectomy and salpingectomy...

Kinetic analysis of interaction of BRCA1 tandem breast cancer c-terminal domain…

Nominé(Yves),Botuyan(Maria Victoria),Bajzer(… Biochemistry 2008-10-20

...BRCA1 (BRCA1-BRCT), an E3 ubiquitin ligase that has been linked to breast and ovarian cancer. While X-ray crystallograph...

Fluorescent resonance energy transfer (FRET) based detection of a multiplex lig…

Ozalp(V Cengiz),Nygren(Anders O H),O'Sulliva… Mol Biosyst 2008-11-18

...BRCA1 exon 13 was present in the test sample. We have verified this assay on a DNA sample of a patient carrying a hetero...

Mouse models for BRCA1 associated tumorigenesis: from fundamental insights to p…

Bouwman(Peter),Jonkers(Jos) Cell Cycle 2008-10-22

...BRCA1, several different knockout mice were generated to study its biological function in vivo. BRCA1, which is involved...

Analysis of the DNA binding activity of BRCA1 and its modulation by the tumour …

Naseem(Riffat),Webb(Michelle) PLoS One 2008-08-20

...BRCA1. In this study we examine the DNA substrate specificity of BRCA1 and how this may be controlled by one of its inte...

Genistein induces apoptosis in ovarian cancer cells via different molecular pat…

Thasni(Karedath Abdul Aziz),Rojini(Gopakumar… Eur J Pharmacol 2008-09-02

...BRCA1 blocked cells and induces estrogen receptor-beta and FAS in presence of BRCA1. It can be concluded that even thoug...

Promoter hypermethylation of BRCA1 correlates with absence of expression in her…

Tapia(Teresa),Smalley(Susan V),Kohen(Paulina… Epigenetics 2008-10-02

...BRCA1/BRCA2 germline mutations. We also determined the presence of the BRCA1 protein in these tumors and correlated both...

Dynamics of DNA repair suggested by the subcellular localization of Brca1 and B…

Huber(L Julie),Chodosh(Lewis A) J Cell Biochem 2008-02-01

...Brca1 and Brca2, may mediate the assembly of protein complexes involved in the repair of damaged DNA, we have performed ...

[Mutational analysis of BRCA1 and BRCA2 genes in early-onset breast cancer pati…

Song(Chuan-gui),Hu(Zhen),Yuan(Wen-tao),Di(Ge… Zhonghua Yi Xue Za Zhi 2008-02-20

...BRCA1, and 4 novel intronic variants in BRCA2, all causing no alteration of amino acid coding. The prevalence of BRCA1 a...

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