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Surveillance for familial breast cancer: Differences in outcome according to BR…

Moller(Pal),Evans(D Gareth),Reis(Marta M),Gr… Int J Cancer 2007-10-04

...BRCA1 was 73% compared to 96% in BRCA2 and 92% in mut neg (p = 0.000). Among BRCA1 mutation-carriers, 5-year survival wa...

The impact of BRCA1 on spina bifida meningomyelocele lesions.

King(Terri M),Au(Kit-Sing),Kirkpatrick(Timot… Ann Hum Genet 2007-12-19

...BRCA1 D17S1323 and the 14GTT allele in BRCA1 D17S1322, and under-transmission of the 20GT allele in BRCA1 D17S1323 and t...

Cancer yield of mammography, MR, and US in high-risk women: prospective multi-i…

Lehman(Constance D),Isaacs(Claudine),Schnall… Radiology 2007-09-12

...BRCA1/BRCA2 carriers or with at least a 20% probability of carrying a BRCA1/BRCA2 mutation. All imaging modalities were ...

Polymorphism in nucleotide excision repair gene XPC correlates with bleomycin-i…

Laczmanska(Izabela),Gil(Justyna),Karpinski(P… Environ Mol Mutagen 2007-12-18

...BRCA1 [homologous recombination], as well as in genes encoding xenobiotic metabolizing enzymes, such as CYP1A, CYP2E1, N...

How could pharmacogenomics help improve patient survival?

Rosell(Rafael),Felip(Enriqueta),Paz-Ares(Lui… Lung Cancer 2007-11-29

...BRCA1 are also determinants of response to cisplatin/gemcitabine, with low levels of mRNA predicting improved survival. ...

Prospective study of Outcomes in Sporadic versus Hereditary breast cancer (POSH…

Eccles(Diana),Gerty(Sue),Simmonds(Peter),Ham… BMC Cancer 2007-10-15

...BRCA1 gene mutation. Preliminary BRCA1 and BRCA2 mutation analysis in a pilot set of study participants confirms we shou...

A mutation in the 5' untranslated region of the BRCA1 gene in sporadic breast c…

Wang(J),Lu(C),Min(D),Wang(Z),Ma(X) J Int Med Res 2007-09-27

...BRCA1 protein in breast tumour samples was evaluated using immunohistochemistry. The mutated 5' UTR of BRCA1 resulted in...

An investigation into 53BP1 complex formation.

Roche(Kevin C),Lowndes(Noel F) Adv Exp Med Biol 2007-09-10

...BRCA1 and in other proteins involved in the DNA damage response, notably budding yeast Rad9. In addition to its recently...

Identification of women with an increased risk of developing radiation-induced …

Cardis(Elisabeth),Hall(Janet),Tavtigian(Sean… Breast Cancer Res 2007-09-14

...BRCA1, BRCA2, ATM or CHEK2 may double the risk of radiation-induced contralateral breast cancer following radiotherapy f...

DNA damage response as an anti-cancer barrier: damage threshold and the concept…

Bartek(Jiri),Lukas(Jiri),Bartkova(Jirina) Cell Cycle 2007-12-06

...BRCA1, BRCA2, p53 and other genes. We propose that carriers of such DDR defects may be more prone to malignancy due to '...

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