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How could pharmacogenomics help improve patient survival?

Rosell(Rafael),Felip(Enriqueta),Paz-Ares(Lui… Lung Cancer 2007-11-29

...BRCA1 are also determinants of response to cisplatin/gemcitabine, with low levels of mRNA predicting improved survival. ...

Identification of FAAP24, a Fanconi anemia core complex protein that interacts …

Ciccia(Alberto),Ling(Chen),Coulthard(Rachel)… Mol Cell 2007-03-27

...BRCA1 and BRCA2. How this complex interacts with damaged DNA is unknown, as only the FA core protein FANCM (the homolog ...

Epigenetic inactivation of the chromosomal stability control genes BRCA1, BRCA2…

Lee(Ming-Ni),Tseng(Ruo-Chia),Hsu(Han-Shui),C… Clin Cancer Res 2007-05-04

...BRCA1 and BRCA2 expression.,The data indicated that low protein expression of BRCA1 and BRCA2 was frequent in lung adeno...

The RAD51 135 G>C polymorphism modifies breast cancer and ovarian cancer risk i…

Jakubowska(Anna),Gronwald(Jacek),Menkiszak(J… Cancer Epidemiol Biomarkers P… 2007-04-03

...BRCA1 mutations. In addition, we were able to show that the site of the BRCA1 mutation does not influence the effect of ...

Compromised Fanconi anemia response due to BRCA1 deficiency in cisplatin-sensit…

Burkitt(Kyunghee),Ljungman(Mats) Cancer Lett 2007-08-21

...BRCA1 since expression of exogenous BRCA1 restored the ability of these cells to induce FANCD2 foci following cisplatin ...

The spectrum and incidence of BRCA1 pathogenic mutations in Slovak breast/ovari…

Konecny(M),Vizvaryova(M),Weismanova(E),Ilenc… Neoplasma 2007-06-28

...BRCA1 and BRCA2 account for the majority of hereditary breast/ovarian cancer cases. The analysis of BRCA1 gene was carri...

Time to decide about risk-reducing mastectomy: a case series of BRCA1/2 gene mu…

McCullum(Mary),Bottorff(Joan L),Kelly(Mary),… BMC Womens Health 2007-07-23

...BRCA1/2 gene mutation.,Data was collected in a pilot study that assessed the response of women to an information booklet...

Counting potentially functional variants in BRCA1, BRCA2 and ATM predicts breas…

Johnson(Nichola),Fletcher(Olivia),Palles(Cla… Hum Mol Genet 2007-08-20

Rare inactivating mutations in BRCA1, BRCA2, ATM, TP53 and CHEK2 confer relative risks for breast cancer between about 2...

The DNA topoisomerase IIbeta binding protein 1 (TopBP1) interacts with poly (AD…

Wollmann(Yvonne),Schmidt(Uta),Wieland(Gerhar… J Cell Biochem 2007-11-29

...BRCA1 C-terminal (BRCT) domain of TopBP1 interacts with a protein fragment of PARP-1 in vitro containing the DNA-binding...

Diagnostic accuracy of methods for the detection of BRCA1 and BRCA2 mutations: …

Gerhardus(Ansgar),Schleberger(Henriette),Sch… Eur J Hum Genet 2007-07-16

As sequence analysis for BRCA1 and BRCA2 mutations is both time- and cost-intensive, current strategies often include sc...

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