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Coincidence of L1 retrotransposition and DNA repair deficiency elicits synthe...

Takahashi(F),Yamamura(T),Oki(S) iScience 2026-09-18

...Brca1 expression that is thought to protect neurons from replication stress. Importantly, L1-mediated pathogenesis corre...

Pregnancy after breast cancer: obstetrics and feto-maternal outcomes.

Fabiani(C),Sanna(F),Guarino(A),Sperduti(I)... Eur Rev Med Pharmacol Sci 2026-08-00

...BRCA1/2-mutated patients. Despite this, the estimated pregnancy achievability in BC survivors is significantly inferior ...

Impact of leuprolide and goserelin on androgen suppression and adverse events...

Freitas(CSM),Rocha-Silva(F),Marques-Silva(... Can J Urol 2026-08-21

...BRCA1, BRCA2, and ATM genes. All treatment groups exhibited significant reductions in PSA and testosterone levels. Leupr...

Unveiling a novel pathway: Ginseng vanillic acid fights heart failure by coup...

Wang(Z),Zhang(L),Liu(C),Yan(S),Wang(M) J Ginseng Res 2026-09-00

...BRCA1 was confirmed by molecular docking, DARTS, CETSA, and SPR. This study demonstrates that VA suppresses NLRP3 inflam...

Integrative transcriptomic- neuroimaging analysis reveals polygenic correlate...

Chen(RB),He(YX),Huang(X),Wang(C) Front Cell Neurosci 2026-00-00

...BRCA1, CDK9, ACTB, and ATP6V1A/F involved in transcriptional regulation, cytoskeletal dynamics, and vesicular acidificat...

NBR1-Mediated Autophagic Degradation of YTHDF1 Curtails FDX1 Translation to D...

Wang(W),Jiang(X),Chen(X),Liang(K),Chen(M),... Cancer Commun (Lond) 2026-00-00

...BRCA1 gene 1 protein (NBR1)-dependent autophagy, leading to the repression of N6-methyladenosine modification-dependent ...

Procyanidin C1 combined with olaparib induces senescence in BRCA1-proficient ...

Ren(C),Fu(C),Chen(X),Yang(R),He(J),Gao(A),... Am J Cancer Res 2026-00-00

...BRCA1-mutated tumors, with BRCA1-proficient patients deriving minimal benefit. Here, we demonstrate that PCC1 persistent...

First-in-Human Study of the PARP Inhibitor HWH340 in Advanced Solid Tumors wi...

Zhang(J),Wang(X),Xu(H),Zang(A),Zhao(J),Che... Drug Des Devel Ther 2026-00-00

...BRCA1/2 mutations and 50% of patients with non-BRCA1/2 HRR gene mutations. No dose-limiting toxicities were detected, an...

BRCA1/2-stratified immune profiling of treatment-naive high-grade serous ovar...

Sharma(M),Kaur(B),Rai(B),Sachdeva(MUS),Sha... J Pathol Transl Med 2026-09-11

...BRCA1/2 was performed in HGSOC, and findings were correlated to immune parameters, chemotherapy response, progression-fr...

LINE-1 insertion intermediates recombine with one another or with DNA breaks ...

Mendez-Dorantes(C),Kalinowski(JC),Burn(A),... Nat Commun 2026-08-01

...BRCA1. In contrast, we find L1 retrotransposition-mediated rearrangements are suppressed by the mismatch repair factor M...

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