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Meta-analysis of BRCA1 and BRCA2 penetrance.

Chen(Sining),Parmigiani(Giovanni) J Clin Oncol 2007-05-15

Genetic counseling is now routinely offered to individuals at high risk of carrying a BRCA1 or BRCA2 mutation. Risk pred...

Meiotic abnormalities in patients bearing complete AZFc deletion of Y chromosom…

Geoffroy-Siraudin(C),Aknin-Seiffer(I),Metzle… Hum Reprod 2007-08-03

...BRCA1 and gammaH2AX. We quantified the leptotene, zygotene and pachytene stages, and pachytene abnormalities: asynapsis ...

Identification of women with an increased risk of developing radiation-induced …

Broeks(Annegien),Braaf(Linde M),Huseinovic(A… Breast Cancer Res 2007-06-13

...BRCA1, BRCA2, CHEK2 and ATM to the risk of radiation-induced contralateral breast cancer (CBC). The germline mutation fr...

Common variants in the ATM, BRCA1, BRCA2, CHEK2 and TP53 cancer susceptibility …

Baynes(Caroline),Healey(Catherine S),Pooley(… Breast Cancer Res 2007-06-13

Certain rare, familial mutations in the ATM, BRCA1, BRCA2, CHEK2 or TP53 genes increase susceptibility to breast cancer ...

Phosphatidylinositol 3-kinase/Akt signaling enhances nuclear localization and t…

Hinton(Cimona V),Fitzgerald(Latricia D),Thom… Exp Cell Res 2007-06-26

...BRCA1 is required for the heregulin-regulated nuclear concentration of BRCA1. Because most functions ascribed to BRCA1 o...

No efficacy of annual gynaecological screening in BRCA1/2 mutation carriers; an…

Hermsen(B B J),Olivier(R I),Verheijen(R H M)… Br J Cancer 2007-09-12

BRCA1/2 mutation carriers are offered gynaecological screening with the intention to reduce mortality by detecting ovari...

Some facts and thoughts: p73 as a tumor suppressor gene in the network of tumor…

Boominathan(Lakshmanane) Mol Cancer 2007-05-11

...BRCA1. Knock out of each gene in E2F-1-p73-JunB-p16INK4a network of tumor suppressor proteins result in lymphoma/leukemi...

Mutator pathways unleashed by epigenetic silencing in human cancer.

Jacinto(Filipe V),Esteller(Manel) Mutagenesis 2007-09-17

...BRCA1 and the Werner syndrome gene WRN become epigenetically silenced in human cancer.

Analysis of PALB2/FANCN-associated breast cancer families.

Tischkowitz(Marc),Xia(Bing),Sabbaghian(Nelly… Proc Natl Acad Sci U S A 2007-06-06

...BRCA1, BRCA2, TP53, CHEK2, ATM, and FANCJ/BRIP1, function in DNA repair, raising the possibility that germ line mutation...

A mechanism for transcriptional repression dependent on the BRCA1 E3 ubiquitin …

Horwitz(Andrew A),Affar(El Bachir),Heine(Geo… Proc Natl Acad Sci U S A 2007-06-06

...BRCA1 protein, we assessed the level of repression dependent on BRCA1 in the cell, and we found that BRCA1 is at least a...

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