BRCA1 and BRCA2 mutations increase breast and ovarian cancer risks substantially enough to warrant risk reduction surger...
The BRCA1 gene product helps to maintain genomic integrity through its participation in the cellular response to DNA dam...
...BRCA1 or BRCA2 genes.,We did a matched case-control study in women who were found to carry a pathogenetic mutation in BR...
...BRCA1/2 mutation were randomly assigned to screening and risk counseling, separately and in combination. Results were co...
...BRCA1 BRCT repeats through a phospho-Ser-X-X-Phe motif. Abraxas binds BRCA1 to the mutual exclusion of BACH1 (BRCA1-asso...
...BRCA1 BRCT domain with RAP80, a ubiquitin-binding protein. RAP80 targets a complex containing the BRCA1-BARD1 (BRCA1-ass...
...BRCA1 or BRCA2 mutations have characteristic morphologic and immunhistochemical features. BRCA1-associated carcinomas ar...
...BRCA1) germline mutation and expression of the human epidermal growth factor receptor 2 (Her2/neu) proto-oncogene seem t...
...BRCA1 interacting genes BRIP1 and ZNF350), non-homologous end-joining (NHEJ) DNA repair (XRCC4) and homologous recombina...
Alterations in the highly penetrant cancer susceptibility gene BRCA1 are responsible for the majority of hereditary brea...
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