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Amyloid precursor protein and amyloid precursor-like protein 2 in cancer.

Pandey(P),Sliker(B),Peters(HL),Tuli(A),Hersk… Oncotarget 2016-04-12

...APLP2 is likewise overexpressed in cancer cells, and APLP2 and APP are linked to increased tumor cell proliferation, mig...

Expression of a ubiquitous, cross-reactive homologue of the mouse beta-amyloid …

Slunt(HH),Thinakaran(G),Von Koch(C),Lo(AC),T… J Biol Chem 1994-01-28

...APLP2 and APP mRNA are expressed in similar, if not identical, neuronal populations and at similar levels. APLP2 appears...

Immunohistochemical and in situ analysis of amyloid precursor-like protein-1 an…

McNamara(MJ),Ruff(CT),Wasco(W),Tanzi(RE),Thi… Brain Res 1998-08-31

...APLP2. We now characterize APLP1 and APLP2 mRNA and protein expression in AD and aged control brains. Using in situ hybr...

APPsα rescues impaired Ca2+ homeostasis in APP- and APLP2-deficient hippocampal…

Ludewig(S),Herrmann(U),Michaelsen-Preusse(K)… Proc Natl Acad Sci U S A 2021-00-29

...APLP2 is still not fully clarified. We now elucidate a mechanism to show how APP and its homolog APLP2 control neuronal ...

Mycobacterium tuberculosis suppresses APLP2 expression to enhance its survival …

Chen(J),Tang(F),Li(H),Wu(X),Yang(Y),Liu(Z),H… Int Immunopharmacol 2023-11-00

...Aplp2 levels in TB patients, M.tb-infected macrophages, and mice. Intriguingly, Aplp2 mutation or knockdown results in d...

Amyloid Precursor-Like Protein 2 deletion-induced retinal synaptopathy related …

Dinet(V),Ciccotosto(GD),Delaunay(K),Borras(C… Mol Brain 2016-00-08

...APLP2 expression affected the retina using APLP2 knockout mice (APLP2-KO). Using histology, morphometric analysis with n...

Tol2 gene trap integrations in the zebrafish amyloid precursor protein genes ap…

Liao(HK),Wang(Y),Noack Watt(KE),Wen(Q),Breit… Dev Dyn 2012-02-00

...aplp2) genes. The transposon integrations are predicted to disrupt the appa and aplp2 genes to primarily produce secrete...

Glutamate toxicity in rat cultured neurones: effects on amyloid precursor-like …

Webster(MT),Amin(N),Pearce(B),Francis(PT) Neurosci Lett 1999-12-03

...APLP2 recovery in the medium but no change in its intracellular level. Both the increase in LDH release and APLP2 recove...

Signaling via amyloid precursor-like proteins APLP1 and APLP2.

Orcholski(ME),Zhang(Q),Bredesen(DE) J Alzheimers Dis 2011-00-00

...APLP2 through interactions with Mint1 and Mint3. APLP1 and APLP2 formed transcriptionally active triple protein complexe...

Gene silencing analyses against amyloid precursor protein (APP) gene family by …

Sakai(T),Hohjoh(H) Cell Biol Int 2006-11-00

Amyloid precursor protein (APP) and amyloid precursor-like proteins 1 and 2 (APLP1 and APLP2) are members of a large gen...

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