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Germline homologous recombination repair (gHRR) variants in bladder cancer: P...

Hurle(R),Capalbo(A),Lughezzani(G),Buffi(NM... BJUI Compass 2025-10-00

...BARD1 (n = 4), CHEK2 (n = 3) and PMS2 (n = 3). Eight patients (34.7%) had multiple variants, and one carried three varia...

Prevalence of Germline Mutations in Genes Engaged in DNA Damage Repair by Hom...

Domagala(Pawel),Jakubowska(Anna),Jaworska-... PLoS One 2016-05-03

...BARD1, and RAD51D, in 202 consecutive patients with triple-negative breast cancers and hereditary non-triple-negative br...

Ubiquitin in regulation of spindle apparatus and its positioning: implication...

Srivastava(Devika),Chakrabarti(Oishee) Biochem Cell Biol 2016-05-16

...BARD1, MGRN1, SMURF2, and SIAH1; these play a pivotal role in the correct positioning of the spindle apparatus. A direct...

Massively Parallel Functional Analysis of BRCA1 RING Domain Variants.

Starita(Lea M),Young(David L),Islam(Muhtad... Genetics 2016-03-16

...BARD1 RING domain. From the resulting scores, we generate a model to predict the capacities of full-length BRCA1 variant...

The BARD1 BRCT domain contributes to p53 binding, cytoplasmic and mitochondri...

Tembe(Varsha),Martino-Echarri(Estefania),M... Cell Signal 2016-03-29

BARD1 is a breast cancer tumor suppressor with multiple domains and functions. BARD1 comprises a tandem BRCT domain at t...

Analysis of large mutations in BARD1 in patients with breast and/or ovarian c...

Klonowska(Katarzyna),Ratajska(Magdalena),C... Sci Rep 2016-03-28

...BARD1. Although it was suggested that large mutations may contribute substantially to the deleterious variants of BARD1,...

BARD1 mediates TGF-β signaling in pulmonary fibrosis.

André(Pierre-Alain),Prêle(Cecilia M),Vierk... Respir Res 2016-07-11

...BARD1 and BARD1β in fibrotic tissues.,Our data suggest that FL BARD1 and BARD1β might be mediators of pleiotropic effect...

BRCA1 and BARD1 colocalize mainly in the cytoplasm of breast cancer tumors, a...

Wiener(David),Gajardo-Meneses(Patricia),Or... Breast Cancer Res Treat 2016-07-11

...BARD1-α and BARD1-β. BRCA1 and BARD1 expressions were performed by immunohistochemistry and immunofluorescence in 103 br...

Interaction of BARD1 and HP1 Is Required for BRCA1 Retention at Sites of DNA ...

Wu(Wenwen),Nishikawa(Hiroyuki),Fukuda(Taka... Cancer Res 2016-01-23

...BARD1 is crucial for its retention through interaction with HP1. In response to DNA damage, BARD1 interacts with Lys9-di...

Functional variant analyses (FVAs) predict pathogenicity in the BRCA1 DNA dou...

Loke(Johnny),Pearlman(Alexander),Upadhyay(... Hum Mol Genet 2016-02-16

...BARD1, PALB2, BRCA2 and FANCD2, phosphorylation of p53 or BRCA1 nuclear localization in response to DNA damage caused by...

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