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Novel African American Colorectal Cancer MSH3 Variants Associate With Major Gen…

Rashid(M),Brim(H),Teng(S),Sobitan(A),Cruz-Co… Hum Mutat None

...MSH2 binding between WT and variant MSH3 proteins. We previously identified six novel, potentially pathogenic nonsynonym...

The 'Prostate Cancer Screening for People at Genetic Risk of Aggressive Disease…

Cheng(HH),Maxwell(KN),Salari(K),Cooperberg(M… BJU Int 2026-06-09

...MSH2, MSH6, CHEK2 and TP53. However, the optimal early detection strategy for gPV carriers, including use of age-adjuste...

Oncological and reproductive outcomes following fertility-preserving treatment …

Zhang(T),Yang(J),Cao(D),Yu(M),Wu(H),Xiang(Y)… BMC Womens Health 2026-05-27

...MSH2/MSH6, and PMS2 expression. Among the 12 patients who underwent germline genetic testing, pathogenic/likely pathogen...

Cancer surveillance in Lynch syndrome: A scoping review of international and na…

McKenzie(M),Quinn(M),Stockley(C),Wood(M),Ish… Genet Med 2026-05-27

...MSH2. Recommendations for extracolonic surveillance varied substantially; most guidelines supported endometrial biopsy a...

Identification of Lynch syndrome among people newly diagnosed with endometrial …

Johnson(JE),Milliken(S),Bolton(J),Evans(DG),… J Med Genet 2026-08-26

...MSH2/MSH6/PMS2 loss and 4/408 were non-hypermethylated) that required germline testing for Lynch syndrome, and 3.2% (13/...

Inhibition of TGM2 enhances cisplatin sensitivity in MSH2-deficient bladder can…

Wei(W),Xiao(X),Ren(C),Zhang(H),Sun(J),Wang(M… Cell Death Discov 2026-05-28

...MSH2 deficiency is not available clinically. Herein, we reported that knockout of MSH2 reduced the sensitivity of BCa to...

Lynch syndrome with MLH1 germline variant in an extended family: a case report.

Duan(Z),Hu(C),Cao(T),Chen(C),Li(Y) Open Life Sci 2026-01-00

...MSH2, MSH6, and PMS2. We report a proband who developed CRC at the age of 52 years and had a family history suggestive o...

Pathogenic Germline Variants in a Racially Diverse Real-World Cohort of Patient…

Crawford(TB),Tayeb(M),Barrett(E),Al-Saleem(T… J Natl Compr Canc Netw 2026-06-02

...MSH2, MSH6, PMS2) were significantly higher compared with a cancer-free cohort of individuals assigned male at birth. In...

Case Report: gastric signet-ring-cell adenocarcinoma in a young adult with trac…

Katrib(A),Babun(A),Wong(L),Reynolds(A),Nishi… Front Oncol None

...MSH2, PMS2, TP53) was negative. Given uncertain tumor location and negative imaging, the patient elected endoscopic surv...

A Rare Case of Seminoma in an Elderly Patient With Suspected Lynch Syndrome.

Kamandi(M),Boozari(M),Soltani(E),Soltani(S) Clin Case Rep 2026-06-00

...MSH2, and PMS2 were preserved. These findings raise suspicion for Lynch syndrome. This case is interesting because semin...

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