...MSH2 binding between WT and variant MSH3 proteins. We previously identified six novel, potentially pathogenic nonsynonym...
...MSH2, MSH6, CHEK2 and TP53. However, the optimal early detection strategy for gPV carriers, including use of age-adjuste...
...MSH2/MSH6, and PMS2 expression. Among the 12 patients who underwent germline genetic testing, pathogenic/likely pathogen...
...MSH2. Recommendations for extracolonic surveillance varied substantially; most guidelines supported endometrial biopsy a...
...MSH2/MSH6/PMS2 loss and 4/408 were non-hypermethylated) that required germline testing for Lynch syndrome, and 3.2% (13/...
...MSH2 deficiency is not available clinically. Herein, we reported that knockout of MSH2 reduced the sensitivity of BCa to...
...MSH2, MSH6, and PMS2. We report a proband who developed CRC at the age of 52 years and had a family history suggestive o...
...MSH2, MSH6, PMS2) were significantly higher compared with a cancer-free cohort of individuals assigned male at birth. In...
...MSH2, PMS2, TP53) was negative. Given uncertain tumor location and negative imaging, the patient elected endoscopic surv...
...MSH2, and PMS2 were preserved. These findings raise suspicion for Lynch syndrome. This case is interesting because semin...
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