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Garofalo(AM),Chotiprasidhi(P),Johnson(JP),... JHEP Rep 2026-08-29

...BRCA1/2-associated hereditary cancer syndromes is recommended in colon or pancreatic cancer patients, but their associat...

Nukaya(T),Naiki(T),Watanabe(H),Nakane(K),I... Int J Urol 2026-09-00

...BRCA1/2 mutations, real-world data in Japanese patients remain limited. We aimed to evaluate the efficacy and safety of ...

San Martín Alonso(M),Kampen(RA),Schreuder(... EMBO Rep 2026-08-27

...BRCA1 encoded by exon 11. Mechanistically, this interaction is required for BRCA1's role in end-resection during homolog...

du Bois(A),Fotopoulou(C),Gardner(GJ),Alett... Int J Gynecol Cancer 2026-08-08

...BRCA1/2 mutations were associated with significantly improved progression-free survival after secondary cytoreduction (2...

Tsutsumi(T),Wada(A),Yamamoto(H),Sato(M),Ts... Bioorg Med Chem 2026-08-26

...BRCA1/2-deficient cancers. We identified (±)-Z250-1659 as a synthetic lethal compound against BAP1-deficient mesotheliom...

van Geelen(CT),Lara Gonzalez(LE),Harris(MA... ESMO Open 2026-08-27

...BRCA1 PVs, and had more ER-negative disease. Diagnosis ≥10 years postpartum was associated with improved OS compared wit...

Hudson-Phillips(SP),Nanda(A),Attia(M),Al Y... Clin Breast Cancer 2026-08-01

Approximately 3% of patients with breast cancer have an inherited pathogenic variant in high-penetrance genes such as BR...

Ruci(A),Smart(C) Cureus 2026-07-00

...BRCA1)/ataxia-telangiectasia mutated (ATM) mutations and invasive lobular carcinoma of the left breast status post bilat...

Akahori(T),Yokotani(T),Yoshizawa(A),Uchiya... Surg Case Rep None

...BRCA1 pathogenic variant. Maintenance olaparib was subsequently introduced, resulting in durable disease stabilization a...

Taki(AG),Shareef(A),Arora(V),Oweis(R),Jyot... Iran J Basic Med Sci None

...BRCA1-deficient tumors. Adaptive AI pipelines that iteratively refine guide RNAs and exosome-mimetic carriers, incorpora...