Women with BRCA1/2 pathogenic variants face increased risks of breast and ovarian cancers. Our study aimed to evaluate t...
...BRCA1/BRCA2-containing complex subunit 3 (BRCC3) in postinfarction cardiac remodeling and dysfunction using a mouse AMI ...
...BRCA1/2 mutant cancers, yet recurrent PARPi resistance frequently develops. The underlying mechanism of PARPi resistance...
...BRCA1/2 play a central role in tumorigenesis and have major implications for targeted therapeutic strategies, especially...
...BRCA1 functions as an obligate heterodimer with its binding partner, the BRCA1-associated RING domain protein 1 (BARD1),...
...BRCA1/2 testing in patients with OC. This study evaluated the pathway and characterised the BRCA1/2 landscape in an Iris...
...BRCA1/2 mutations was 9.0% (95% CI: 7.7-10.4%). Subgroup analyses showed a higher prevalence for BRCA1 mutations (10.5%,...
...BRCA1 and BRCA2 genes. This study represents the first and largest investigation of germline CNVs in the BRCA1 and BRCA2...
...Brca1 gene, classically known for its tumor-suppressive role in mammary tissue, also plays a crucial role in maintaining...
...BRCA1/2 gene variant carriers. Risk-adapted approaches are gaining interest but are underexplored. To assess the feasibi...
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