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BRCA1 promotes induction of ssDNA by ionizing radiation.

Schlegel(Brian P),Jodelka(Francine M),Nunez(… Cancer Res 2006-07-18

...BRCA1 into nuclear foci in response to induction of DNA breaks suggests that BRCA1 may function in an early step in the ...

Acetyl-CoA carboxylase alpha is essential to breast cancer cell survival.

Chajès(Véronique),Cambot(Marie),Moreau(Karen… Cancer Res 2006-07-18

...BRCA1, which indicates a possible connection between lipid synthesis and genetic factors involved in susceptibility to b...

Telomerase template antagonist GRN163L disrupts telomere maintenance, tumor gro…

Hochreiter(Amelia E),Xiao(Hongling),Goldblat… Clin Cancer Res 2006-07-26

...BRCA1 mutant breast tumor cells as well as doxorubicin-resistant cancer cells. To investigate the in vivo effects of GRN...

Structure and E3-ligase activity of the Ring-Ring complex of polycomb proteins …

Buchwald(Gretel),van der Stoop(Petra),Weiche… EMBO J 2006-08-14

...BRCA1/BARD1 complex, but complex formation depends on an N-terminal arm of Ring1b that embraces the Bmi1 Ring-domain. Mu...

Cost-effectiveness of screening BRCA1/2 mutation carriers with breast magnetic …

Plevritis(Sylvia K),Kurian(Allison W),Sigal(… JAMA 2006-05-26

Women with inherited BRCA1/2 mutations are at high risk for breast cancer, which mammography often misses. Screening wit...

BRCA1 phosphorylation: biological consequences.

Ouchi(Toru) Cancer Biol Ther 2006-11-21

...BRCA1 kinases, the identification of the phosphorylation residues, and the biological consequences of BRCA1's phosphoryl...

Polymorphisms in genes involved in DNA double-strand break repair pathway and s…

Shen(Min),Lan(Qing),Zhang(Luoping),Chanock(S… Carcinogenesis 2006-11-13

...BRCA1, BRCA2, XRCC3 and XRCC4) in a study of 250 workers exposed to benzene and 140 controls in China. Four SNPs in WRN ...

Total-genome analysis of BRCA1/2-related invasive carcinomas of the breast iden…

Weber(Frank),Shen(Lei),Fukino(Koichi),Patocs… Am J Hum Genet 2006-06-30

...BRCA1/2-related breast cancers provide an impaired mammary stroma that could facilitate later malignant transformation o...

Chromosome 2q24.2 is lost in sporadic but not in BRCA1-associated ovarian carci…

Aghmesheh(Morteza),Suo(Zhenhe),Friedlander(M… Pathology 2006-06-08

...BRCA1-associated group (p = 0.385).,Our data do not support the association between copy number gain at 2q24-32 and BRCA...

Breast MRI as a screening tool: the appropriate role.

Le-Petross(Huong T) J Natl Compr Canc Netw 2006-10-25

...BRCA1 and BRCA2 mutations. Recent studies show improved specificity of MRI, likely related to advances in technique and ...

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