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Dos Santos(ES),Cicilini(AL),Simões(MFE),Ba... Int J Mol Sci 2026-07-28

Poly(ADP-ribose) polymerase inhibitors (PARPis) have demonstrated remarkable efficacy in tumors carrying BRCA1/2 pathoge...

Abinawanto,Sophian(A) Environ Mol Mutagen 2026-06-00

...BRCA1/2-mutant tumors. Despite initial efficacy, resistance inevitably emerges, limiting long-term clinical benefit. Thi...

Abdel-Razeq(H),Bani Hani(H),Alafeef(S),Tam... Front Oncol None

...BRCA1 P/LP variants were identified. Germline P/LP variants are common in young male patients with cancer, particularly ...

Gao(J),Wang(S),Huang(A),Wang(H),Xiao(Z) AME Case Rep None

...BRCA1 mutation. After completion of multidisciplinary neoadjuvant systemic therapy, the patient underwent E-NSM with imm...

Steenbock(O),Rieger(C),Heidenreich(J),Paff... Urol Int 2026-08-13

...BRCA1/2, CDK12, CTNNB1, DLL3, ETS family, FOXA1, FOXO1, MED12, PIK3CA, PTEN, RAD51C, TP53, Wnt-Pathway). Since 2023, we ...

Kapoor(A),Uthale(S),Chain(A),Rungta(A),Ano... JCO Glob Oncol 2026-08-00

...BRCA1/2, potentially underidentifying patients with other HRR gene variants who could benefit from targeted therapies. A...

Kamau(K),Byrne(L),Goradia(R),Sundi(D),Meng... Eur Urol Oncol 2026-08-13

...BRCA1, BRCA2, and ATM. Very small cohorts of patients with UC and LS or a DDR variant responded well to immune checkpoin...

Kay(J),Harris(MA),Lara Gonzalez(LE),van Ge... Immunooncol Technol 2026-09-00

...BRCA1 (gBRCA1) pathogenic variants (PVs) are the most common cause of inherited breast cancer. Preclinical studies have ...

Kabeer(F),Cochrane(D),Grisdale(C),Lynch(BJ... Gynecol Oncol Rep 2026-08-00

...BRCA1 mutation with somatic loss of heterozygosity (LOH), resulting in biallelic BRCA1 loss. A high HRDetect score (0.96...

Yoshioka(KI),Matsuno(Y),Kusumoto-Matsuo(R) Cancer Sci 2026-08-14

...BRCA1/2 mutations. However, many cancers exhibiting genomic instability occur without detectable defects in canonical re...