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Disruption of BRCA1 function results in telomere lengthening and increased anap…

French(Juliet D),Dunn(Jasmyn),Smart(Chanel E… Genes Chromosomes Cancer 2006-03-28

...BRCA1 mutation carriers and Brca1-null mice also raises the possibility that BRCA1 plays a role in telomere protection. ...

Improving the accuracy of BRCA1/2 mutation prediction: validation of the novel …

Capalbo(Carlo),Ricevuto(Enrico),Vestri(Annar… Eur J Hum Genet 2006-04-13

...BRCA1/2 gene mutation. Whether the IC or other country-customized models might improve BRCA1/2 mutation prediction also ...

Younger birth cohort correlates with higher breast and ovarian cancer risk in E…

Kroiss(Regina),Winkler(Verena),Bikas(Diana),… Hum Mutat 2006-06-13

Mutations in the BRCA1 gene result in an elevated risk of breast cancer (BC) and ovarian cancer (OC). However, risk esti...

Methylation and expression analysis of 15 genes and three normally-methylated g…

Imura(Masayoshi),Yamashita(Satoshi),Cai(Li-Y… Cancer Lett 2006-11-09

...BRCA1 was not methylated at all. Aberrant demethylation of MAGE-A3, -B2 and -A1 was detected in 8, 4 and 3 cell lines, r...

Multiplexed DNA sequencing-by-synthesis.

Aksyonov(Sergei A),Bittner(Michael),Bloom(Li… Anal Biochem 2006-06-13

...BRCA1 gene. For a 20,000-spot array, readout rates in excess of 6000 bases per minute are projected.

BRCA1 genetic mutation and its link to ovarian cancer: implications for advance…

Brunsvold(Amy N),Wung(Shu-Fen),Merkle(Carrie… J Am Acad Nurse Pract 2006-03-02

...BRCA1 gene and ovarian cancer and (b) BRCA1 testing and its related issues. This review is aimed for nurse practitioners...

53BP1 oligomerization is independent of its methylation by PRMT1.

Adams(Melissa M),Wang(Bin),Xia(Zhenfang),Mor… Cell Cycle 2006-05-04

...BRCA1 C-terminal repeats, tandem Tudor domains, and a variety of phosphorylation sites. Here we show that a glycine-argi...

Efficient deletion of normal Brca2-deficient intestinal epithelium by poly(ADP-…

Hay(Trevor),Jenkins(Helen),Sansom(Owen J),Ma… Cancer Res 2006-01-18

...BRCA1 and BRCA2 tumor suppressors are the most commonly mutated in human familial breast cancers. Both have separate rol...

BRCA1 and c-Myc associate to transcriptionally repress psoriasin, a DNA damage-…

Kennedy(Richard D),Gorski(Julia J),Quinn(Jen… Cancer Res 2006-01-18

...BRCA1-repressed targets. We show that functional BRCA1 is required for repression of these family members and that a BRC...

Roles of heterogeneous nuclear ribonucleoproteins A and B in cell proliferation.

He(Yaowu),Brown(Melissa A),Rothnagel(Joseph … J Cell Sci 2006-01-10

...BRCA1 was downregulated, at both mRNA and protein levels. The observed effects of hnRNP A2 and its isoforms on cell prol...

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