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Evaluation of models to predict BRCA germline mutations.

Kang(H H),Williams(R),Leary(J),,Ringland(C... Br J Cancer 2006-11-14

...BRCA1/2 mutation analysis. Sensitivity, specificity, positive and negative predictive values, likelihood ratios and area...

CHK2-dependent phosphorylation of BRCA1 in hypoxia.

Gibson(Shannon L),Bindra(Ranjit S),Glazer(... Radiat Res 2006-11-20

...BRCA1 protein, plays a critical role in both DNA repair and cell cycle checkpoint regulation in mammalian cells. Here we...

Regulation of TopBP1 oligomerization by Akt/PKB for cell survival.

Liu(Kang),Paik(Jason C),Wang(Bing),Lin(Fan... EMBO J 2006-12-04

...BRCA1 carboxyl-terminal) domain-containing protein, which interacts with E2F1 but not other E2Fs and represses its proap...

The estrogen receptor alpha C975G variant in familial and sporadic breast can...

Skoglund(Johanna),Margolin(Sara),Zhou(Xiao... Anticancer Res 2006-09-19

...BRCA1/2 familial and 191 high-risk non-BRCA1/2 familial breast cancer cases and 653 controls.,There was a lower frequenc...

Abnormalities of the inactive X chromosome are a common feature of BRCA1 muta...

Ganesan(S),Richardson(A L),Wang(Z C),Igleh... Cold Spring Harb Symp Quant... 2006-09-08

...BRCA1, it is a sporadic phenocopy of most cases of BRCA1(/) breast cancer. Not only do the cells of the two tumors resem...

The ATM-dependent DNA damage signaling pathway.

Kitagawa(R),Kastan(M B) Cold Spring Harb Symp Quant... 2006-09-08

...BRCA1 proteins appears to be in the recruitment of an activated ATM kinase molecule to the sites of DNA breaks so that A...

Exploiting the DNA repair defect in BRCA mutant cells in the design of new th...

Tutt(A N J),Lord(C J),McCabe(N),Farmer(H),... Cold Spring Harb Symp Quant... 2006-09-08

...BRCA1 or BRCA2 genes are at highly elevated risk of a variety of cancers. Ten years of research has revealed roles for B...

Breast cancer susceptibility testing: past, present and future.

Goldberg(Jessica I),Borgen(Patrick I) Expert Rev Anticancer Ther 2006-09-27

...BRCA1 or BRCA2 tumor-suppressor genes. The functions of the BRCA proteins are not fully understood, although it is clear...

Maternal dietary exposure to fiber during pregnancy and mammary tumorigenesis...

Yu(Bin),Khan(Galam),Foxworth(Aaron),Huang(... Int J Cancer 2006-11-13

...BRCA1 and p53 were significantly increased in the mammary glands of whole wheat flour offspring. Further, the levels of ...

Using the impact of event scale to evaluate distress in the context of geneti...

Dorval(Michel),Drolet(Mélanie),LeBlanc(Mél... Psychol Rep 2006-09-26

The data obtained with two forms of the Impact of Event Scale were compared, one referring to a BRCA1/2 test result (IES...

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