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The critical mutagenic translesion DNA polymerase Rev1 is highly expressed du...

Waters(Lauren S),Walker(Graham C) Proc Natl Acad Sci U S A 2006-09-11

...BRCA1 C-terminal) domain of Saccharomyces cerevisiae Rev1 for mutagenesis and the interaction of the C-terminal region o...

Variation in the RAD51 gene and familial breast cancer.

Lose(Felicity),Lovelock(Paul),Chenevix-Tre... Breast Cancer Res 2006-09-27

...BRCA1 and BRCA2. Similar to BRCA1 mice, RAD51-/- mice are embryonic lethal. The RAD51 gene region has been shown to exhi...

Positive selection in the evolution of cancer.

Crespi(Bernard J),Summers(Kyle) Biol Rev Camb Philos Soc 2006-09-21

...BRCA1, the angiogenesis gene ANG, cadherin genes, cytochrome P450 genes, and viral oncogenes; and (2) large-scale databa...

Phenotypic features and genetic characterization of male breast cancer famili...

Miolo(GianMaria),Puppa(Lara Della),Santaro... BMC Cancer 2006-11-14

...BRCA1/2 testing. Here we report on the genetic and phenotypic characterization of 10 families with MBC from the North Ea...

Predictors of occult neoplasia in women undergoing risk-reducing salpingo-oop...

Lamb(Julie D),Garcia(Rochelle L),Goff(Barb... Am J Obstet Gynecol 2006-06-23

...BRCA1 mutation would be predictors for tubal or ovarian neoplasia and that a careful surgical and pathologic protocol wo...

Cost-effectiveness of screening BRCA1/2 mutation carriers with breast magneti...

Plevritis(Sylvia K),Kurian(Allison W),Siga... JAMA 2006-05-26

Women with inherited BRCA1/2 mutations are at high risk for breast cancer, which mammography often misses. Screening wit...

Polymorphisms in genes involved in DNA double-strand break repair pathway and...

Shen(Min),Lan(Qing),Zhang(Luoping),Chanock... Carcinogenesis 2006-11-13

...BRCA1, BRCA2, XRCC3 and XRCC4) in a study of 250 workers exposed to benzene and 140 controls in China. Four SNPs in WRN ...

High frequency of BRCA1 5382insC mutation in Russian breast cancer patients.

Sokolenko(Anna P),Mitiushkina(Natalia V),B... Eur J Cancer 2006-09-11

...BRCA1 5382insC allele on BC incidence in St Petersburg, Russia. High frequency of the BRCA1 5382insC allele was detected...

An ATR- and BRCA1-mediated Fanconi anemia pathway is required for activating ...

Zhu(Wenge),Dutta(Anindya) Mol Cell Biol 2006-07-17

...BRCA1, or FANCA is absent. Therefore, the ATR- and BRCA1-mediated FA pathway is required for the activation of a G2/M ch...

Depletion of CHK1, but not CHK2, induces chromosomal instability and breaks a...

Durkin(S G),Arlt(M F),Howlett(N G),Glover(... Oncogene 2006-11-08

...BRCA1 and FANCD2 play critical roles in maintaining the stability of fragile site regions. To further elucidate the path...

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