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Prophylactic salpingo-oophorectomy in 51 women with familial breast-ovarian c...

Leunen(K),Legius(E),Moerman(P),Amant(F),Ne... Int J Gynecol Cancer 2006-05-17

...BRCA1 mutation was found in 35% of the tested group, while 30% were BRCA2 carriers. Mean age at intervention was 45.3 ye...

Newly diagnosed breast cancer patients choose bilateral mastectomy over breas...

Stolier(Alan J),Corsetti(Ralph L) Am Surg 2006-02-22

...BRCA1/2 mutation, decisions as to whether to undergo prophylactic risk-reduction surgery may differ from those women who...

Establishment of three human breast epithelial cell lines derived from carrie...

Rubner Fridriksdottir(Agla J),Gudjonsson(T... In Vitro Cell Dev Biol Anim 2006-10-05

...BRCA1 and BRCA2 account for a large proportion of inherited breast and ovarian cancer. Both genes are involved in DNA re...

A conserved pathway to activate BRCA1-dependent ubiquitylation at DNA damage ...

Polanowska(Jolanta),Martin(Julie S),Garcia... EMBO J 2006-07-21

...BRCA1 and UbcH5c to form an active E3-Ub ligase on chromatin after IR. These data reveal that BRCA1-dependent ubiquityla...

Cell cycle-dependent DNA damage signaling induced by ICRF-193 involves ATM, A...

Park(Iha),Avraham(Hava Karsenty) Exp Cell Res 2006-08-04

...BRCA1, MDC1, and FANCD2 and increased comet tail moment. The DNA damage signaling induced by ICRF-193 was mediated by AT...

BRCA1 downregulation leads to premature inactivation of spindle checkpoint an...

Chabalier(C),Lamare(C),Racca(C),Privat(M),... Cell Cycle 2006-06-05

BRCA1 germline mutations predispose women to early onset, familial breast and ovarian cancer. BRCA1 has been recently im...

Ten-year multi-institutional results of breast-conserving surgery and radioth...

Pierce(Lori J),Levin(Albert M),Rebbeck(Tim... J Clin Oncol 2006-06-12

...BRCA1/2 mutation carriers with breast cancer versus that of matched sporadic controls.,A total of 160 BRCA1/2 mutation c...

Genetic factors in ovarian carcinoma.

Li(A J),Karlan(B Y) Curr Oncol Rep 2005-05-18

...BRCA1, and BRCA2; mismatch repair genes such as hMSH2 and hMLH1; and PTEN, HER-2/neu, K-ras, fms, and AKT2. Novel genes ...

The DNA crosslink-induced S-phase checkpoint depends on ATR-CHK1 and ATR-NBS1...

Pichierri(Pietro),Rosselli(Filippo) EMBO J 2005-06-20

...BRCA1, ATM and the RAD50/MRE11/NBS1 (RMN) complex. We deciphered the previously undefined pathway(s) leading to the ICLs...

TopBP1 localises to centrosomes in mitosis and to chromosome cores in meiosis...

Reini(Kaarina),Uitto(Lahja),Perera(David),... Chromosoma 2005-01-07

...BRCA1 and p53. Spindle checkpoint activation does not affect this centrosomal localisation. Moreover, in the testis, we ...

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