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Melanoma cells express elevated levels of phosphorylated histone H2AX foci.

Warters(Raymond L),Adamson(Patrick J),Pond... J Invest Dermatol 2005-05-16

...BRCA1, 53BP1, and Nbs1 foci in untreated melanoma cells indicated that the additional foci in melanoma cells were associ...

Inactivation of CtIP leads to early embryonic lethality mediated by G1 restra...

Chen(Phang-Lang),Liu(Feng),Cai(Suna),Lin(X... Mol Cell Biol 2005-06-14

...BRCA1, Ikaros, and CtBP, which regulate cell cycle progression through transcriptional repression as well as chromatin r...

NBS1 and its functional role in the DNA damage response.

Kobayashi(Junya),Antoccia(Antonio),Tauchi(... DNA Repair (Amst) 2005-02-14

...BRCA1 C-terminus (BRCT) domain at the N-terminus, several SQ motifs (consensus phosphorylation sites by ATM and ATR kina...

The DNA double-strand break response pathway: becoming more BRCAish than ever...

Ting(Nicholas S Y),Lee(Wen-Hwa) DNA Repair (Amst) 2005-02-14

...Brca1 has been intimately linked with various aspects of this signaling pathway. However, the precise role of Brca1 in t...

MDC1/NFBD1: a key regulator of the DNA damage response in higher eukaryotes.

Stucki(Manuel),Jackson(Stephen P) DNA Repair (Amst) 2005-02-14

...BRCA1 carboxyl-terminal (BRCT) domains. It interacts with several proteins involved in DNA damage repair and checkpoint ...

Acetyl-CoA carboxylase alpha gene and breast cancer susceptibility.

Sinilnikova(Olga M),Ginolhac(Sophie M),Mag... Carcinogenesis 2005-01-13

The identification of an interaction between BRCA1 and acetyl-CoA carboxylase alpha (ACCalpha), a key enzyme in lipid sy...

Microelectronic DNA assay for the detection of BRCA1 gene mutations.

Chen(Hua),Han(Jie),Li(Jun),Meyyappan(Meyya... Biomed Microdevices 2005-01-11

Mutations in BRCA1 are characterized by predisposition to breast cancer, ovarian cancer and prostate cancer as well as c...

Nonrandom distribution of aberrant promoter methylation of cancer-related gen...

Parrella(Paola),Poeta(Maria Luana),Gallo(A... Clin Cancer Res 2005-02-17

...BRCA1, p16, ESR1, GSTP1, TRbeta1, RARbeta2, HIC1, APC, CCND2, and CDH1 genes.,The majority of the breast cancer (85%) sh...

Dominant prostasome immunogens for sperm-agglutinating autoantibodies of infe...

Carlsson(Lena),Ronquist(Gunnar),Nilsson(B ... J Androl 2005-02-02

...BRCA1-associated ring domain protein 1, heat shock 27-kd protein, isocitrate dehydrogenase, lactoylglutathione lyase, NG...

RNA analysis reveals splicing mutations and loss of expression defects in MLH...

Sharp(Andrew),Pichert(Gabriella),Lucassen(... Hum Mutat 2005-03-10

...BRCA1. In addition, allele-specific analysis of common coding polymorphisms identified a further case of monoallelic BRC...

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