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Time to reconsider subcutaneous mastectomy for breast-cancer prevention?

Metcalfe(Kelly A),Semple(John L),Narod(Ste... Lancet Oncol 2005-06-23

...BRCA1 and BRCA2, we are identifying more and more women who have an 80% or more lifetime risk of developing breast cance...

Human relevance of rodent prolactin-induced non-genotoxic mammary carcinogene...

Harvey(Philip W) J Appl Toxicol 2005-08-23

...BRCA1. It is now clear that initial studies giving dopamine agonists to breast cancer patients had no effect because bre...

Mutational analysis of the BRCA1 gene in 30 Czech ovarian cancer patients.

Zikan(M),Pohlreich(P),Stribrna(J) J Genet 2005-06-14

...BRCA1 and BRCA2 gene alterations are found in the majority of these cases. The aim of this study was to analyse the BRCA...

Mechanisms of alcohol-associated cancers: introduction and summary of the sym...

Purohit(Vishnudutt),Khalsa(Jag),Serrano(Jose) Alcohol 2005-11-30

...BRCA1 and increased estrogen responsiveness (primarily in breast); and (7) impairment of retinoic acid metabolism. Nicot...

Structure of the BRCT repeat domain of MDC1 and its specificity for the free ...

Lee(Megan S),Edwards(Ross A),Thede(Gina L)... J Biol Chem 2005-10-20

...BRCA1 BRCT bound to a phosphopeptide, we suggest that two arginine residues in MDC1, Arg(1932) and Arg(1933) may recogni...

Cyclin D1 antagonizes BRCA1 repression of estrogen receptor alpha activity.

Wang(Chenguang),Fan(Saijun),Li(Zhiping),Fu... Cancer Res 2005-10-04

...BRCA1-mediated repression of estrogen receptor alpha (ERalpha)-dependent gene expression. Cyclin D1 repression of BRCA1 ...

Advances in the understanding of risk factors for ovarian cancer.

Bandera(Christina A) J Reprod Med 2005-12-22

...BRCA1 and BRCA2 genes and is associated with an 11-40% risk of developing ovarian cancer. The hereditary nonpolyposis co...

BRCA1 in breast and ovarian cancer predisposition.

Billack(Blase),Monteiro(Alvaro N A) Cancer Lett 2005-09-08

Women carrying one mutated BRCA1 allele are at increased risk of developing breast and ovarian cancer but tumor initiati...

Specific binding of the methyl binding domain protein 2 at the BRCA1-NBR2 locus.

Auriol(Emilie),Billard(Lise-Marie),Magdini... Nucleic Acids Res 2005-08-09

...BRCA1, and the Near BRCA1 2 (NBR2) gene. In HeLa cells, quantitative chromatin immunoprecipitation assays indicated that...

Risk reduction of contralateral breast cancer and survival after contralatera...

van Sprundel(T C),Schmidt(M K),Rookus(M A)... Br J Cancer 2005-09-27

The clinical outcome of contralateral prophylactic mastectomy (CPM) in women with a BRCA1 or BRCA2 mutation and a person...

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