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Dong(M),Hua(J),Ma(Z),Tang(R),Wei(M),Lv(Z),... Cancer Med 2026-07-00

...BRCA1/2 and PALB2 mutations showed a trend towards improved survival with platinum-containing regimens, although statist...

Abad(CB),Deza(DC),Campillo(FM),Fuente(NP),... Cancers (Basel) 2026-08-11

...BRCA1/2 or PALB2, variants with established therapeutic relevance, while eight (28.6%) carried ATM, FANCA, or FANCM, var...

MoghaddamHosseini(V),Zand(A) Cancers (Basel) 2026-08-21

...BRCA1/2 carriers, and it is supported prospectively by the POSITIVE trial, whose preplanned update at a median follow-up...

Guzauskas(GF),Berger(SM),O'Connor(R),Kim(S... Genet Med 2026-08-26

Reclassification of variants of uncertain significance in BRCA1/2 impact clinical management, health outcomes, and healt...

Tran(MT),Williamson(EA),Jaiswal(AS),Arris(... Nucleic Acids Res 2026-08-24

Given their defect in homologous recombination, BRCA1-deficient cancers use polymerase theta (POLQ) microhomology-mediat...

Cao(Y),Jalil(ZA),Mu(X),Stringer(JM),Zerafa... Front Endocrinol (Lausanne) None

...Brca1 fl/fl Gdf9 +/+) and oocyte-specific Brca1 conditional knockout (cKO; Brca1 fl/fl Gdf9 cre/+) mice were treated wit...

Ghosh(A),Ran(X),Zhang(F),Gao(B),Xu(Y),Phoo... Nat Commun 2026-08-10

...BRCA1-deficient cancer cells, broader cancer dependencies on TRDMT1 remain unclear. Here, a TRDMT1 inhibitor (TRDMT1i) s...

Tarar Jasim(M),Motovali-Bashi(M) Int J Fertil Steril 2026-08-08

...Brca1 gene, classically known for its tumor-suppressive role in mammary tissue, also plays a crucial role in maintaining...

Das(PR),Rahman(MJ),Nirob(SR),Patwary(MO),I... Front Oncol 2026-00-00

...BRCA1/PARP, as benchmarks for GNN-based discovery frameworks. Despite encouraging progress, current evidence remains lar...

Jin(H),Jeon(KH),Kang(C),Lee(J),Lee(Y),Kwon... Oncol Rep 2026-11-00

...BRCA1 deletion mutant analyses suggested that the BRCA1 C‑terminal domain may contribute to the effect of Peme on BRCA1 ...