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A novel transcription factor Rwdd1 and its SUMOylation inhibit the expression o…

Li(X),Liu(X),Qin(Z),Wei(M),Hou(X),Zhang(T),Z… Aquat Toxicol 2018-11-00

...NF1 and Sp1 have been verified to participate in its transcriptional regulation. In this study, we obtained 23 potential...

Molecular-targeted therapy for childhood low-grade glial and glioneuronal tumor…

Siegel(BI),Duke(ES),Kilburn(LB),Packer(RJ) Childs Nerv Syst 2024-10-00

...NF1 loss; however, even in this population, gliomas arising in late childhood and adolescence or those not responding to...

Transposon mutagenesis identifies chromatin modifiers cooperating with Ras in t…

Montero-Conde(C),Leandro-Garcia(LJ),Chen(X),… Proc Natl Acad Sci U S A 2017-00-20

...NF1 mutations. Expression of ATXN7 mutants cooperated with oncogenic RAS to induce thyroid cell proliferation, pointing ...

Higher methylation subtype of malignant melanoma and its correlation with thick…

Yamamoto(Y),Matsusaka(K),Fukuyo(M),Rahmutull… Cancer Med 2020-00-00

...NF1 as the most frequently mutated driver genes. While epigenetic aberrations are known to contribute to the oncogenic a...

Image segmentation of plexiform neurofibromas from a deep neural network using …

Ho(CY),Kindler(JM),Persohn(S),Kralik(SF),Rob… Sci Rep 2020-00-20

...NF1 Patients were recruited from a phase II clinical trial for the treatment of PN. Multiple b-value DWI was imaged over...

A Novel Orthotopic Patient-Derived Xenograft Model of Radiation-Induced Glioma …

Whitehouse(JP),Howlett(M),Hii(H),Mayoh(C),Wo… Cancers (Basel) 2020-10-12

...NF1, and a gain-of-function mutation in PTPN11. Additionally, deletion of CDKN2A/B, increased IDH1 expression, and decre...

Recent Advances in Histopathological and Molecular Diagnosis in Pheochromocytom…

Yamazaki(Y),Gao(X),Pecori(A),Nakamura(Y),Tez… Front Endocrinol (Lausanne) 2020-00-00

...NF1, TMEM127, MAX, and others. Such genetic alterations are mainly involved in the pathogenesis of pseudohypoxia, Wnt, a...

Malignant peripheral nerve sheath tumors - Outcomes and prognostic factors base…

Sobczuk(P),Teterycz(P),Czarnecka(AM),Świtaj(… Surg Oncol 2020-12-00

...NF1 positive). Median OS was 126.5 months and 5-year survival rate was 61.9% in the group treated with curative intent. ...

Integrated genomic analysis identifies a genetic mutation model predicting resp…

Jiang(J),Ding(Y),Wu(M),Chen(Y),Lyu(X),Lu(J),… Cancer Med 2020-00-00

...NF1 and SERPINB3/4. Overall, these findings deserve prospective investigation in the future and may help guide clinical ...

Clinical significance of tumor mutation burden and DNA damage repair in advance…

Zhang(H),Deng(YM),Chen(ZC),Tang(YC),Yang(S),… Eur Rev Med Pharmacol Sci 2020-00-00

...NF1, DNMT3A, ALK, MYC, PIK3CA, ROS1, BRAF, ARID1A, PTEN, CDKN2A, and FGF19 genes. We also identified many mutations in t...

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