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Hörner(M),Hartkopf(A),John(N),Ziegler(P),H... NPJ Breast Cancer 2026-04-11

Germline BRCA1 and BRCA2 mutations enable targeted therapies in human epidermal growth factor receptor 2 (HER2)-negative...

Ye(D),Zhao(Y),Yang(L),Sun(X),Cao(T),Yuan(M... Clin Genitourin Cancer 2026-06-00

...BRCA1/2 mutations in ctDNA were linked to inferior PFS, whereas BRCA1/2 mutations did not significantly worsen OS. About...

Li(J),Mu(D),Li(J),Lan(M),Wu(W),Zhang(S),Da... Transl Oncol 2026-06-00

...BRCA1/2 mutations and non-malignant diseases. Although PARPi has been known to affect the energy metabolism of cells, it...

Quinto Pereira(M),Miguel(I),Fragoso(S),Dua... Cureus 2026-03-00

...BRCA1 and 74% in BRCA2 families), followed by other cases of prostate cancer (42% in BRCA1 vs. 34% in BRCA2). The median...

Georgy(DM),Sedeek(HN),Abaza(NE),Eldeeb(SEK... Biochem Biophys Rep 2026-06-00

The Breast Cancer gene 1 (BRCA1) and Breast Cancer gene 2 (BRCA2) genes are pivotal human tumor suppressor genes that ar...

Matsuoka(T),Akamatsu(S),Ong(CJ),Gleave(ME)... Cells 2026-03-26

...BRCA1/2-altered tumors, especially BRCA2, and most responders eventually relapse. Here, we frame PARPi response and resi...

Grimm(MO),Gratzke(C),Hadaschik(B),Eiber(M)... Urologie 2026-05-00

...BRCA1/2, is essential for the indication of poly(ADP-ribose) polymerase inhibitors (PARPI), which can be used as monothe...

Williams(SCP) Proc Natl Acad Sci U S A 2026-04-21

...BRCA1-mutant tumors treated with talazoparib, pointing to new combination therapies. She emphasizes the value of mentors...

Balkwill(FR),Laumont(CM),Burdett(N),Le Sau... Nat Rev Cancer 2026-06-00

...BRCA1 or BRCA2 (BRCA1/BRCA2) mutations of any cancer type and is a highly chromosomally unstable disease. Despite the in...

Prihharsanti(CHN),Prajoko(YW),Respati(DRP)... Cancers (Basel) 2026-03-29

...BRCA1, BRCA2, CHEK2, and ATM. While radiotherapy (RT) is a crucial component of breast cancer (BC) treatment, its potent...