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An RNF11: Smurf2 complex mediates ubiquitination of the AMSH protein.

Li(Haoxia),Seth(Arun) Oncogene 2004-05-13

...BRCA1-dependent manner. Eps15 is monoubiquitinated and is part of an essential complex involved in the endocytosis of pl...

Screening adherence in BRCA1/2 families is associated with primary physicians...

Tinley(Susan T),Houfek(Julia),Watson(Patri... Am J Med Genet A 2004-07-28

...BRCA1/2 mutation. Participants in the study included 112 women (33 mutation carriers and 79 at 50% risk). Data was colle...

Survival and recurrence after breast cancer in BRCA1/2 mutation carriers.

El-Tamer(Mahmoud),Russo(Donna),Troxel(Andr... Ann Surg Oncol 2004-05-13

...BRCA1/2 mutation carriers and noncarriers.,Using the Columbia Presbyterian breast cancer database, we collected the tiss...

Digital detection of genetic mutations using SPC-sequencing.

Ruparel(Hameer),Ulz(Michael E),Kim(Sobin),... Genome Res 2004-03-16

...BRCA1 gene mutations 185delAG and 5382insC as examples. In this method, Sanger DNA sequencing fragments are generated in...

Ovarian cancer and polymorphisms in the androgen and progesterone receptor ge...

Modugno(Francesmary) Am J Epidemiol 2004-04-06

...BRCA1/2) genes, are inconclusive. There is insufficient evidence that polymorphisms in either the PGR gene or the AR gen...

BRCA1/BARD1 orthologs required for DNA repair in Caenorhabditis elegans.

Boulton(Simon J),Martin(Julie S),Polanowsk... Curr Biol 2004-02-26

...BRCA1 predispose individuals to early onset breast and ovarian cancer. BRCA1 together with its structurally related part...

BRCA1 functions as a breast stem cell regulator.

Foulkes(W D) J Med Genet 2004-02-24

...BRCA1 and its rodent homologues and the clinicopathological features of breast cancer related to BRCA1 support the notio...

Cytoplasmic mislocalization of BRCA1 caused by cancer-associated mutations in...

Rodriguez(José Antonio),Au(Wendy W Y),Hend... Exp Cell Res 2004-03-11

...BRCA1-5382insC mutant (deleted BRCT domain) in HCC1937 breast cancer cells. Unlike wild-type BRCA1, the BRCA1-5382insC m...

Brca1 expression is regulated by a bidirectional promoter that is shared by t...

Whitehouse(Caroline),Chambers(Julie),Catte... Gene 2004-03-16

The lack of functionally disrupting mutations of BRCA1 in sporadic breast tumours has suggested that other mechanisms, i...

Prepubertal estradiol and genistein exposures up-regulate BRCA1 mRNA and redu...

Cabanes(Anna),Wang(Mingyue),Olivo(Susan),D... Carcinogenesis 2004-06-14

...BRCA1, a tumor suppressor gene that participates in DNA damage repair processes and cell differentiation and that down-r...

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