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Microcephalin is a DNA damage response protein involved in regulation of CHK1...

Xu(Xingzhi),Lee(Juhie),Stern(David F) J Biol Chem 2004-09-24

...Brca1 but not exogenous Brca1. Mcph1 inhibition also decreases both endogenous and heterologous Chk1 transcripts and pro...

BRCA1 inhibits membrane estrogen and growth factor receptor signaling to cell...

Razandi(Mahnaz),Pedram(Ali),Rosen(Eliot M)... Mol Cell Biol 2004-08-04

...BRCA1 (but not mutant BRCA1). E2 induced the synthesis of cyclins D1 and B1, the activity of cyclin-dependent kinases Cd...

BRCA1 interacts with and is required for paclitaxel-induced activation of mit...

Gilmore(Paula M),McCabe(Nuala),Quinn(Jenni... Cancer Res 2004-08-06

...BRCA1 disease-associated mutations abrogated the interaction in yeast, and BRCA1 failed to interact with MEKK3 in BRCA1 ...

Fanconi anaemia and leukaemia - clinical and molecular aspects.

Tischkowitz(Marc),Dokal(Inderjeet) Br J Haematol 2004-08-31

...BRCA1 and BRCA2. This review summarizes the general clinical and specific haematological features and the current manage...

Analysis of missense variation in human BRCA1 in the context of interspecific...

Abkevich(V),Zharkikh(A),Deffenbaugh(A M),F... J Med Genet 2004-12-21

...BRCA1, BRCA2, MLH1, MSH2, TP53, and PTEN, is becoming an increasingly important part of clinical practice. Interpretatio...

ERBB2, TBX2, RPS6KB1, and MYC alterations in breast tissues of BRCA1 and BRCA...

Adem(Camilo),Soderberg(Cheryl L),Hafner(Ka... Genes Chromosomes Cancer 2004-08-24

...BRCA1 or BRCA2 genes. Because breast cancer initiation is different between BRCA1/2 mutation carriers and women who do n...

Ionizing radiation inhibits the PLK cell cycle gene in a G2 checkpoint-depend...

Ree(Anne Hansen),Bratland(Ase),Solberg Lan... Anticancer Res 2004-07-19

...BRCA1 genotype of the HCC1937/BRCA1wt cell line was associated with significant down-regulation of PLK mRNA expression a...

Ubiquitination and proteasomal degradation of the BRCA1 tumor suppressor is r...

Choudhury(Atish D),Xu(Hong),Baer(Richard) J Biol Chem 2004-10-25

...BRCA1 gene can account for induction of BRCA1 expression at the G1/S transition, the mechanisms by which BRCA1 is down-r...

Analysis of cell cycle progression and genomic integrity in early lethal knoc...

Brown(Eric J) Methods Mol Biol 2004-09-09

...BRCA1, BRCA2, or Rad51 leads to developmental arrest prior to gastrulation. While prior to arrest the number of cells ex...

Genes related to growth regulation, DNA repair and apoptosis in an oestrogen ...

Skog(Sven),He(Qimin),Khoshnoud(Reza),Forna... Tumour Biol 2004-07-08

...BRCA1, BRCA2, cdc2, cyclin B1, cyclin D1, cyclin E, IGFBP-3, TGF-alpha, TGF beta 2 and a lower expression of TGF beta R1...

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