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A gene-environment interaction between occupation and BRCA1/BRCA2 mutations i...

Palli(Domenico),Masala(Giovanna),Mariani-C... Eur J Cancer 2004-12-27

The association of male breast cancer (MBC) with a positive breast cancer (BC) family history and with BRCA1/2 germ-line...

Hallmarks of 'BRCAness' in sporadic cancers.

Turner(Nicholas),Tutt(Andrew),Ashworth(Ala... Nat Rev Cancer 2004-11-19

Germline mutations in the BRCA1, BRCA2 and Fanconi anaemia genes confer cancer susceptibility, and the proteins encoded ...

The role of BRCA1 in the cellular response to chemotherapy.

Kennedy(Richard D),Quinn(Jennifer E),Mulla... J Natl Cancer Inst 2004-12-08

...BRCA1 gene account for approximately 5% of breast and ovarian cancer cases, and lower than normal BRCA1 expression or fu...

Attitudes toward preventive oophorectomy among BRCA1 mutation carriers in Pol...

Menkiszak(J),Rzepka-Górska(I),Górski(B),Gr... Eur J Gynaecol Oncol 2004-06-15

Currently genetic testing for BRCA1 and BRCA2 susceptibility genes is performed throughout Europe and North America. In ...

Clinical features of familial ovarian cancer lacking mutations in BRCA1 or BR...

Menkiszak(J),Gronwald(J),Górski(B),Byrski(... Eur J Gynaecol Oncol 2004-06-15

...BRCA1 or BRCA2 gene.,303 patients with ovarian cancer were reviewed for clinical features and for cancer family historie...

Loss of heterozygosity of the BRCA1 and FHIT genes in patients with sporadic ...

Santos(S C L),Cavalli(L R),Cavalli(I J),Li... J Clin Pathol 2004-05-13

...BRCA1 intragenic marker.,The frequency of allelic losses in the FHIT and BRCA1 loci in the Southern Brazilian population...

The cell cycle checkpoint kinase Chk2 is a negative regulator of mitotic cata...

Castedo(Maria),Perfettini(Jean-Luc),Roumie... Oncogene 2004-07-01

...BRCA1 nuclear bodies when the cells arrest at the G2/M boundary. Inhibition of Chk2 by transfection of a dominant-negati...

Molecular epidemiology of breast cancer: a review.

Okobia(M N),Bunker(C H) Afr J Reprod Health 2004-04-22

...BRCA1, BRCA2 and p53 confer a high risk for an individual, they represent a low overall attributable risk due to low all...

Epidemiology of breast cancer among BRCA mutation carriers: an overview.

Nkondjock(André),Ghadirian(Parviz) Cancer Lett 2004-04-28

Mutations in BRCA1 and BRCA2 have been associated with an increased lifetime risk of breast and ovarian cancers. Many of...

Physical mechanisms and biological significance of supramolecular protein sel...

Kentsis(Alex),Borden(Katherine L B) Curr Protein Pept Sci 2004-10-26

...BRCA1:BARD1 with regard to assembly of supramolecular enzymes with metabolic and chemically directive functions. In addi...

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